{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:57:43Z","timestamp":1791925063600,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31200886"],"award-info":[{"award-number":["31200886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015M580856"],"award-info":[{"award-number":["2015M580856"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Brown and beige adipose tissues dissipate energy in the form of heat via mitochondrial uncoupling protein 1, defending against hypothermia and potentially obesity. The latter has prompted renewed interest in understanding the processes involved in browning to realize the potential therapeutic benefits. To characterize the temporal profile of cold\u2010induced changes and browning of brown and white adipose tissues in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male C57BL\/6J mice were singly housed in conventional cages under cold exposure (4\u00a0\u00b0C) for 1, 2, 3, 4, 5 and 7\u00a0days. Food intake and body weight were measured daily. Interscapular brown adipose tissue (iBAT), inguinal subcutaneous (sWAT) and epididymal white adipose tissue (eWAT) were harvested for histological, immunohistochemical, gene and protein expression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Upon cold exposure, food intake increased, whilst body weight and adipocyte size were found to be transiently reduced. iBAT mass was found to be increased, whilst sWAT and eWAT were found to be transiently decreased. A combination of morphological, genetic (<jats:italic>Ucp\u20101, Pgc\u20101\u03b1 and Elov13<\/jats:italic>) and biochemical (UCP\u20101, PPAR\u03b3 and aP2) analyses demonstrated the depot\u2010specific remodelling in response to cold exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate the differential responses to cold\u2010induced changes across discrete BAT and WAT depots and support the notion that the effects of short\u2010term cold exposure are achieved by expansion, activation and increasing thermogenic capacity of iBAT, as well as browning of sWAT and, to a lesser extent, eWAT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12688","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T07:52:39Z","timestamp":1460361159000},"page":"311-324","source":"Crossref","is-referenced-by-count":70,"title":["Characterization of cold\u2010induced remodelling reveals depot\u2010specific differences across and within brown and white adipose tissues in mice"],"prefix":"10.1111","volume":"217","author":[{"given":"R.","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of China Xi'an Jiaotong University Xi'an China"},{"name":"Department of Prosthodontics College of Stomatology, Stomatological Hospital Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010Q.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Public Health Xi'an Jiaotong University Health Science Center Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology Boston University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010X.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of China Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of China Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of China Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of China Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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