{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:27:33Z","timestamp":1784762853514,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["H201302"],"award-info":[{"award-number":["H201302"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Renal denervation (<jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>) has beneficial effects on cardiac remodelling and function in resistant hypertension. We aimed to investigate the impact of <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> on cardiac angiogenesis during prolonged pressure overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cardiac pressure overload was reproduced by transverse aorta constriction (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) procedure in adult Sprague Dawley male rats (<jats:italic>n<\/jats:italic>\u00a0=\u00a035). <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>\/sham\u2010<jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> procedure was performed in surviving rats at 5\u00a0weeks after <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five weeks post\u2010<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>, transthoracic echocardiography revealed that myocardial hypertrophy occurred in <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> rats, with ejection fraction and fractional shortening not significantly changed. At the end of 10\u00a0weeks, cardiac systolic function was preserved in <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> group, but not in sham group. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31 immunohistochemical staining showed that <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>\u2010treated rats had higher cardiac capillary density than sham rats. However, no significant between\u2010group difference was observed in the kidneys. A decreased protein expression of left ventricle vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) was observed in sham group, while <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> attenuated this decrease. Compared with sham, <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> resulted in a higher protein expression of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> receptor 2 (<jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>2) and phosphorylated endothelial nitric oxide synthase (p\u2010e<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) in the heart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Renal denervation benefits cardiac angiogenesis during sustained pressure overload, involving regulation of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>2 expression as well as activation of e<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12793","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T14:51:55Z","timestamp":1472568715000},"page":"47-57","source":"Crossref","is-referenced-by-count":21,"title":["Beneficial effects of renal denervation on cardiac angiogenesis in rats with prolonged pressure overload"],"prefix":"10.1111","volume":"220","author":[{"given":"D.","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 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