{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:35:41Z","timestamp":1789724141268,"version":"4.0.1"},"reference-count":183,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001861","name":"Forskningsr\u00e5det f\u00f6r Arbetsliv och Socialvetenskap","doi-asserted-by":"publisher","award":["FAS: 2011\u20100627"],"award-info":[{"award-number":["FAS: 2011\u20100627"]}],"id":[{"id":"10.13039\/501100001861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR: 2009\u20103640"],"award-info":[{"award-number":["VR: 2009\u20103640"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR: 2015\u201000495"],"award-info":[{"award-number":["VR: 2015\u201000495"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006516","name":"Bertil H\u00e5llstens Forskningsstiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006516","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["INCA 600398"],"award-info":[{"award-number":["INCA 600398"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several explanations for the diverse results in research on foetal alcohol spectrum disorders or alcohol\u2010related neurodevelopmental disorder might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and post\u2010natal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed. Special focus is put on the serotonergic system within developmental and gene\u2013environment frameworks. The review also suggests guidelines for future studies and also summarizes some of to\u2010be\u2010answered questions of relevance to clinical practice. Contradictory findings and paucity of studies on the effects of exposure to low alcohol levels during foetal life for the offspring's neuropsychological development call for large prospective studies, as well as for studies including neuroimaging and multi\u2010omics analyses to dissect the neurobiological underpinnings of alcohol exposure\u2010related phenotypes and to identify biomarkers. Finally, it remains to be investigated whether any safe threshold of alcohol drinking during pregnancy can be identified.<\/jats:p>","DOI":"10.1111\/apha.12892","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T08:02:50Z","timestamp":1493884970000},"source":"Crossref","is-referenced-by-count":36,"title":["Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure"],"prefix":"10.1111","volume":"222","author":[{"given":"E.","family":"Comasco","sequence":"first","affiliation":[{"name":"Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rangmar","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. J.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Oreland","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91092-1"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Fetal alcohol syndrome prevention team, DoBD, developmental disabilities, NCoBD, developmental disabilities, CfDC, prevention: guidelines for identifying and referring persons with fetal alcohol syndrome","volume":"54","author":"Bertrand J","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9166-x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01661.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0259"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4256"},{"key":"e_1_2_10_8_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems","author":"World Health Organisation","year":"1992"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3319"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01783.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-780"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00498.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12208"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12027"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006323","article-title":"Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies","volume":"5","author":"O'Keeffe LM","year":"2015","journal-title":"BMJ Open"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000117868.97486.2D"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3109\/08039488.2015.1009487","article-title":"Cognitive and executive functions, social cognition and sense of coherence in adults with fetal alcohol syndrome","volume":"69","author":"Rangmar J","year":"2015","journal-title":"Nord J Psychiatry"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1915"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.68"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000156125.50577.EC"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.12.1654"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1990.tb01224.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12214"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12073"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12486"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2007.02.009"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02756.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.067"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03393.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12246"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03396.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03397.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12008"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12006"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2009.103002"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02596.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn230"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.5.815"},{"key":"e_1_2_10_39_1","first-page":"e323","article-title":"Investigating the effects of low to moderate levels of prenatal alcohol exposure on child behaviour: a critical review","volume":"17","author":"Todorow M","year":"2010","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00417.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agg087"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02716.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12203"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01163.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1909"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600989211"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010028"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.07.025"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdrb.20137","article-title":"Computational models of ethanol\u2010induced neurodevelopmental toxicity across species: implications for risk assessment","volume":"83","author":"Gohlke JM","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.03.002"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gdata.2016.10.007","article-title":"Gene expression in the mouse brain following early pregnancy exposure to ethanol","volume":"10","author":"Zhang CR","year":"2016","journal-title":"Genom Data"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.10.012"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.048"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060503"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010975"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2013.03.010"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci6020012","article-title":"Epigenetic mechanisms in developmental alcohol\u2010induced neurobehavioral deficits","volume":"6","author":"Basavarajappa BS","year":"2016","journal-title":"Brain Sci"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801311-3.00001-9"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-179234"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9164-z"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043067"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.10.007"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-141572"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<94::AID-HIPO11>3.0.CO;2-T"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100309"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(97)00039-1"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(97)00041-X"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.03.007"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06049.x"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000100940.95053.72"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00075.2015"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12224"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02480.x"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.165027"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.alc.0000187037.02670.59"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.08.007"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-29"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890903531582"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.11.002"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.05.012"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.02.014"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01266.x"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607037104"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.06.013"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01644.x"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01132.x"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2015.04.001"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2014.00093"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2016.11.004"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32831b449c"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21311"},{"key":"e_1_2_10_92_1","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci6040052","article-title":"Prenatal alcohol exposure affects progenitor cell numbers in olfactory bulbs and dentate gyrus of vervet monkeys","volume":"6","author":"Burke MW","year":"2016","journal-title":"Brain Sci"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/34.3.402"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2012.04.009"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-005-9017-8"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66062621.x"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902740211"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050816"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.4.621"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000949"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.11.1146"},{"key":"e_1_2_10_102_1","first-page":"2006","article-title":"Risk, resilience, and gene\u00a0\u00d7\u00a0environment interactions in rhesus monkeys","volume":"52","author":"Suomi SJ","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.07.017"},{"key":"e_1_2_10_104_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/neuro.07.030.2009","article-title":"Timing of moderate level prenatal alcohol exposure influences gene expression of sensory processing behavior in rhesus monkeys","volume":"3","author":"Schneider ML","year":"2009","journal-title":"Front Integr Neurosci"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01421.x"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12151"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2000.61.46"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2882604"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02441.x"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20595"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.21976"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.37"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0652-8"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl192"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.90"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm140"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.08.038"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.07.022"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1256"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1463"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01294726"},{"key":"e_1_2_10_122_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fncel.2013.00143","article-title":"Lack of serotonin reuptake during brain development alters rostral raphe\u2010prefrontal network formation","volume":"7","author":"Witteveen JS","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009730903573246"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083968"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005936"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-007-9172-1"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.01.011"},{"key":"e_1_2_10_128_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2478\/s13380-013-0121-6","article-title":"Serotonin transporter genotype by environment: studies on alcohol use and misuse in non\u2010human and human primates","volume":"4","author":"Todkar A","year":"2013","journal-title":"Transl Neurosci"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30132"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-010-9356-y"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00238.x"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.12.017"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-009-9285-9"},{"key":"e_1_2_10_134_1","article-title":"Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene\u2013environment interactions of BDNF Val66Met, 5\u2010HTTLPR, and MAOA\u2010uVNTR","volume":"18","author":"Nilsson KW","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114570600705X"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0495-z"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.03.001"},{"key":"e_1_2_10_138_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-3-642-28720-6_142","article-title":"Non\u2010human primate models of alcohol\u2010related phenotypes: the influence of genetic and environmental factors","volume":"13","author":"Barr CS","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.44"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.024"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2013.34"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0694-8"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579411000071"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.73"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/ab.21451"},{"key":"e_1_2_10_146_1","first-page":"e201","article-title":"Alcohol consumption among women","volume":"20","author":"Zelner I","year":"2013","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2216"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02327.x"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1177\/1541204011422087"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214529508"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.03.012"},{"key":"e_1_2_10_152_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/YPG.0b013e32834371e8","article-title":"Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents","volume":"21","author":"Hiio K","year":"2011","journal-title":"Psychiatr Genet"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.09.010"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05919"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.01.009"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09230"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12622"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12655"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn289"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.12.026"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1276"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12175"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2270"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012201"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200502080-00020"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.04.006"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30657"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2009.12.003"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.3.2.6034"},{"key":"e_1_2_10_170_1","first-page":"29","article-title":"Focus on: epigenetics and fetal alcohol spectrum disorders","volume":"34","author":"Kobor MS","year":"2011","journal-title":"Alcohol Res Health"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.12.80"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.12.77"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.60"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32278"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-6-r43"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-016-0074-4"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798007867"},{"key":"e_1_2_10_178_1","first-page":"56","article-title":"Focus on: biomarkers of fetal alcohol exposure and fetal alcohol effects","volume":"34","author":"Bakhireva LN","year":"2011","journal-title":"Alcohol Res Health"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.11.009"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40474-014-0020-8"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.02.003"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579413000655"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1993"},{"key":"e_1_2_10_184_1","article-title":"Personality as an intermediate phenotype for genetic dissection of alcohol use disorder","author":"Oreland L","year":"2017","journal-title":"J Neural Transm"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.12892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:42:33Z","timestamp":1695966153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":183,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/apha.12892"],"URL":"https:\/\/doi.org\/10.1111\/apha.12892","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]},"article-number":"e12892"}}