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Right ventricular (RV) longitudinal function is impaired in patients with free pulmonary regurgitation (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) following corrective surgery for Tetralogy of Fallot (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>). It remains unclear whether this is a consequence of the surgical repair, or whether it is inherent to <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>. The aim of this study was to assess the relationship between longitudinal, lateral and septal pumping in a porcine model of isolated <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Piglets were divided into a control (<jats:italic>n<\/jats:italic> = 8) group and a treatment (<jats:italic>n<\/jats:italic> = 12) group, which received a stent in the pulmonary valve orifice, inducing <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>. After 2\u20133 months, animals were subjected to cardiac magnetic resonance imaging. A subset of animals (<jats:italic>n<\/jats:italic> = 6) then underwent percutaneous pulmonary valve replacement (<jats:styled-content style=\"fixed-case\">PPVR<\/jats:styled-content>) with follow\u2010up 1 month later. Longitudinal, lateral and septal contributions to stroke volume (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>) were quantified by measuring volumetric displacements from end\u2010diastole to end\u2010systole in the cardiac short axis and long axis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PR resulted in a lower longitudinal contribution to <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> stroke volume, compared to controls (60.0 \u00b1 2.6% vs. 73.6 \u00b1 3.8%; <jats:italic>P<\/jats:italic> = 0.012). Furthermore, a compensatory increase in septal contribution to <jats:styled-content style=\"fixed-case\">RVSV<\/jats:styled-content> was observed (11.0 \u00b1 1.6% vs. \u22123.1 \u00b1 1.5%; <jats:italic>P<\/jats:italic> &lt; 0.0001). The left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) showed counter\u2010regulation with an increased longitudinal <jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content>. Changes in <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> longitudinal function were reversed by <jats:styled-content style=\"fixed-case\">PPVR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> contributes to decreased <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> longitudinal function in the absence of scarring from cardiac surgery. Measurement of longitudinal <jats:styled-content style=\"fixed-case\">RVSV<\/jats:styled-content> may aid risk stratification and timing for interventional correction of <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12904","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T07:18:38Z","timestamp":1496647118000},"page":"163-173","source":"Crossref","is-referenced-by-count":15,"title":["Isolated pulmonary regurgitation causes decreased right ventricular longitudinal function and compensatory increased septal pumping in a porcine model"],"prefix":"10.1111","volume":"221","author":[{"given":"S.","family":"Kopic","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Stephensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Heiberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"},{"name":"Department of Biomedical Engineering Faculty of Engineering Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Arheden","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Clinical Physiology Sk\u00e5ne University Hospital Lund University Lund 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