{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:02:14Z","timestamp":1787594534722,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009776","name":"McMaster University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003400","name":"Ministry of Research, Innovation and Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We compared the control of breathing and heart rate by hypoxia between high\u2010 and low\u2010altitude populations of <jats:italic>Peromyscus<\/jats:italic> mice, to help elucidate the physiological specializations that help high\u2010altitude natives cope with O<jats:sub>2<\/jats:sub> limitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Deer mice (<jats:italic>Peromyscus maniculatus<\/jats:italic>) native to high altitude and congeneric mice native to low altitude (<jats:italic>Peromyscus leucopus<\/jats:italic>) were bred in captivity at sea level. The F1 progeny of each population were raised to adulthood and then acclimated to normoxia or hypobaric hypoxia (12 kPa, simulating hypoxia at ~4300 m) for 5 months. Responses to acute hypoxia were then measured during stepwise reductions in inspired O<jats:sub>2<\/jats:sub> fraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lowlanders exhibited ventilatory acclimatization to hypoxia (<jats:styled-content style=\"fixed-case\">VAH<\/jats:styled-content>), in which hypoxia acclimation enhanced the hypoxic ventilatory response, made breathing pattern more effective (higher tidal volumes and lower breathing frequencies at a given total ventilation), increased arterial O<jats:sub>2<\/jats:sub> saturation and heart rate during acute hypoxia, augmented respiratory water loss and led to significant growth of the carotid body. In contrast, highlanders did not exhibit <jats:styled-content style=\"fixed-case\">VAH<\/jats:styled-content> \u2013 exhibiting a fixed increase in breathing that was similar to hypoxia\u2010acclimated lowlanders \u2013 and they maintained even higher arterial O<jats:sub>2<\/jats:sub> saturations in hypoxia. However, the carotid bodies of highlanders were not enlarged by hypoxia acclimation and were similar in size to those of normoxic lowlanders. Highlanders also maintained consistently higher heart rates than lowlanders during acute hypoxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that highland deer mice have evolved high rates of alveolar ventilation and respiratory O<jats:sub>2<\/jats:sub> uptake without the significant enlargement of the carotid bodies that is typical of <jats:styled-content style=\"fixed-case\">VAH<\/jats:styled-content> in lowlanders, possibly to adjust the hypoxic chemoreflex for life in high\u2010altitude hypoxia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12912","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T17:12:40Z","timestamp":1498151560000},"page":"266-282","source":"Crossref","is-referenced-by-count":74,"title":["Control of breathing and ventilatory acclimatization to hypoxia in deer mice native to high altitudes"],"prefix":"10.1111","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-4423","authenticated-orcid":false,"given":"C. M.","family":"Ivy","sequence":"first","affiliation":[{"name":"Department of Biology McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Biology McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,8]]},"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.12912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:13:24Z","timestamp":1696018404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/apha.12912"],"URL":"https:\/\/doi.org\/10.1111\/apha.12912","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,8]]}}}