{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:49:42Z","timestamp":1785451782077,"version":"3.56.0"},"reference-count":176,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3 310"],"award-info":[{"award-number":["P3 310"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD078678"],"award-info":[{"award-number":["HD078678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intracellular organelles, including secretory vesicles, emerged when eukaryotic cells evolved some 3 billion years ago. The primordial organelles that evolved in Archaea were similar to endolysosomes, which developed, arguably, for specific metabolic tasks, including uptake, metabolic processing, storage and disposal of molecules. In comparison with prokaryotes, cell volume of eukaryotes increased by several orders of magnitude and vesicle traffic emerged to allow for communication between distant intracellular locations. Lysosomes, first described in 1955, a prominent intermediate of endo\u2010 and exocytotic pathways, operate virtually in all eukaryotic cells including astroglia, the most heterogeneous type of homeostatic glia in the central nervous system. Astrocytes support neuronal network activity in particular through elaborated secretion, based on a complex intracellular vesicle network dynamics. Deranged homeostasis underlies disease and astroglial vesicle traffic contributes to the pathophysiology of neurodegenerative (Alzheimer's disease, Huntington's disease), neurodevelopmental diseases (intellectual deficiency, Rett's disease) and neuroinfectious (Zika virus) disorders. This review addresses astroglial cell\u2010autonomous vesicular traffic network, as well as its into primary and secondary vesicular network defects in diseases, and considers this network as a target for developing new therapies for neurological conditions.<\/jats:p>","DOI":"10.1111\/apha.12915","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T15:12:34Z","timestamp":1498835554000},"source":"Crossref","is-referenced-by-count":30,"title":["Astroglial vesicular network: evolutionary trends, physiology and pathophysiology"],"prefix":"10.1111","volume":"222","author":[{"given":"R.","family":"Zorec","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrinology and Molecular Cell Physiology Institute of Pathophysiology University of Ljubljana Ljubljana Slovenia"},{"name":"Celica BIOMEDICAL Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Parpura","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Civitan International Research Center and Center for Glial Biology in Medicine Evelyn F. McKnight Brain Institute Atomic Force Microscopy and Nanotechnology Laboratories University of Alabama Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Verkhratsky","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrinology and Molecular Cell Physiology Institute of Pathophysiology University of Ljubljana Ljubljana Slovenia"},{"name":"Celica BIOMEDICAL Ljubljana Slovenia"},{"name":"Faculty of Biology Medicine and Health The University of Manchester Manchester UK"},{"name":"Achucarro Center for Neuroscience IKERBASQUE Basque Foundation for Science Bilbao Spain"},{"name":"Department of Neurosciences University of the Basque Country UPV\/EHU and CIBERNED Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"20130595","DOI":"10.1098\/rstb.2015.0428","article-title":"The homeostatic astroglia emerges from evolutionary specialization of neural cells","volume":"371","author":"Verkhratsky A","year":"2016","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"e_1_2_14_3_1","first-page":"277","article-title":"Physiopathologic dynamics of vesicle traffic in astrocytes","volume":"26","author":"Potokar M","year":"2011","journal-title":"Histol Histopathol"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.09.011"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.020"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-004-1375-x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35058528"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440050202"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.08.008"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.02.007"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07664.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.11.008"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1513-1"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.10.037"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-10-03293.1987"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592705"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.107.5.1347"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20110061"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.08.010"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.02.033"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1545-x"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4576"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2013.09.001"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1841"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/202358"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-52-1-7"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5430.1033"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032658599"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14447"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04546"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.3.759"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.153"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2010.502516"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0600604"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0905-847"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3565"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.9.4.773"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.20.3.497"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.02.002"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8063-2"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858410387304"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.1.99"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22964"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.003"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22626"},{"key":"e_1_2_14_48_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000209823","article-title":"\u00dcber die Neuroglia marginalis der menschlichen Grosshirnrinde","volume":"26","author":"Held H","year":"1909","journal-title":"Mschr Psychol Neurol"},{"key":"e_1_2_14_49_1","unstructured":"J Nageotte 1910 1068 1069"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20018"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01580.2003"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-08894-5_5"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2015.00056"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-144"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.4.1292"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.01.011"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3742-14.2015"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.05.028"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.10.004"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22575"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04042.x"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22981"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww298"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506486112"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.229518.113"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086178"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.02.027"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200806137"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.11.009"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13754"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21000"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01025.2002"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/369744a0"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.21.6712"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050387"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.069"},{"key":"e_1_2_14_78_1","article-title":"Astrocytic vesicle\u2010based exocytosis in cultures and acutely isolated hippocampal rodent slices","author":"Jorgacevski J","year":"2017","journal-title":"J Neurosci Res"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr254"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1849"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607625104"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.210435"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2213-2"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700290200"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0185-11.2011"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.06.012"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3109\/09687681003597104"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.02.030"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80400-6"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7950"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01389"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X687750"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140611238"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.08.020"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20597"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.119"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.020"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.034"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402144"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2013"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.03.025"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-805088-0.00001-3"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.11.014"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20967"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.89"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9562-y"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21290"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2006.00509.x"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.772020"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv464"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22931"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0168-16.2016"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2011.02337.x"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2013.03.005"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22293"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9834-1"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086219"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507084595"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22485"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071121"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22361"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13715"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3579-11.2011"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201208152"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.163"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.061"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.1116"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1993.12.651"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(84)80029-7"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.55.2.366"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05351.x"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095023"},{"key":"e_1_2_14_134_1","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.4161\/auto.22184","article-title":"Autophagy in astrocytes: a novel culprit in lysosomal storage disorders","volume":"8","author":"Malta C","year":"2012","journal-title":"Autophagy"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00206-1"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10543-10555.2004"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.04.007"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.05.013"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2014.08.013"},{"key":"e_1_2_14_141_1","first-page":"600","article-title":"Physiology and pharmacological role of the blood\u2010brain barrier","volume":"60","author":"Bernacki J","year":"2008","journal-title":"Pharmacol Rep"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.11.007"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09613"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_14_145_1","first-page":"12","article-title":"Energy metabolism in neurodevelopment and medulloblastoma","volume":"4","author":"Tech K","year":"2015","journal-title":"Transl Pediatr"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.11.020"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.045"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2303"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1983.63.3.844"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21161"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13630"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4284"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00434-3"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1159375"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0054-3"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.124"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140107"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.11.5959"},{"issue":"6","key":"e_1_2_14_160_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1242\/jcs.112.6.785","article-title":"Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II\u2010containing compartments","volume":"112","author":"Wubbolts R","year":"1999","journal-title":"J Cell Sci"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7199"},{"issue":"13","key":"e_1_2_14_162_1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1242\/jcs.111.13.1791","article-title":"Actin microfilaments control the MHC class II antigen presentation pathway in B cells","volume":"111","author":"Barois N","year":"1998","journal-title":"J Cell Sci"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200611147"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1276"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.08.028"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1352\/0047-6765(2001)039<0047:NDACIM>2.0.CO;2"},{"key":"e_1_2_14_167_1","first-page":"1109","article-title":"Finding genes on the X chromosome by which homo may have become sapiens","volume":"58","author":"Turner G","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/487"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2728"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.21.2567"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn321"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10214"},{"key":"e_1_2_14_173_1","first-page":"213","article-title":"A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya)","volume":"12","author":"Chun J","year":"2011","journal-title":"Discov Med"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3248"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440010402"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13561"},{"key":"e_1_2_14_177_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10545-014-9772-x","article-title":"Type I glycogen storage diseases: disorders of the glucose\u20106\u2010phosphatase\/glucose\u20106\u2010phosphate transporter complexes","volume":"38","author":"Chou JY","year":"2013","journal-title":"J Inherit Metab Dis"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.12915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.12915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T19:50:03Z","timestamp":1695844203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,3]]},"references-count":176,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/apha.12915"],"URL":"https:\/\/doi.org\/10.1111\/apha.12915","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,3]]},"article-number":"e12915"}}