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During this period, subjects completed supervised knee\u2010extensor resistance training where one leg was subjected to training with maximal volitional effort in each repetition using a flywheel ergometer (<jats:styled-content style=\"fixed-case\">FW<\/jats:styled-content>), while the other leg performed conventional (work\u2010matched across groups) weight\u2010stack training (<jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content>). Before and after training, muscle volume (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and strength were assessed, and muscle biopsies were analysed for gene and protein expression of muscle growth regulators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The increase in m. quadriceps volume was similar between <jats:styled-content style=\"fixed-case\">FW<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content>, yet was (averaged across legs) greater in <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> (7.5%) compared with <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content> (3.7%, group difference 34\u00a0cm<jats:sup>3<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029). In the <jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content> leg, muscle strength improved similarly (11\u201320%) across groups. In the <jats:styled-content style=\"fixed-case\">FW<\/jats:styled-content> leg, increases (10\u201323%) in muscle strength were evident in both groups yet they were generally greater (interaction effects <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) for <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>. While our molecular analysis revealed several training effects, the only group interaction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) arose from a downregulated <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maximal over\u2010the\u2010counter doses of ibuprofen attenuate strength and muscle hypertrophic adaptations to 8\u00a0weeks of resistance training in young adults. Thus, young individuals using resistance training to maximize muscle growth or strength should avoid excessive intake of anti\u2010inflammatory drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.12948","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T07:42:41Z","timestamp":1503301361000},"source":"Crossref","is-referenced-by-count":77,"title":["High doses of anti\u2010inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults"],"prefix":"10.1111","volume":"222","author":[{"given":"M.","family":"Lilja","sequence":"first","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Stockholm Sweden"},{"name":"Unit of Clinical Physiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mandi\u0107","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Stockholm Sweden"},{"name":"Unit of Clinical Physiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Apr\u00f3","sequence":"additional","affiliation":[{"name":"\u00c5strand Laboratory Swedish School of Sport and Health Sciences Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Melin","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Stockholm Sweden"},{"name":"Unit of Clinical Physiology Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Cardiology Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Olsson","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Stockholm Sweden"},{"name":"Unit of Clinical Physiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rosenborg","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Stockholm Sweden"},{"name":"Unit of Clinical Physiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-6230","authenticated-orcid":false,"given":"T. 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