{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T15:38:16Z","timestamp":1768750696501,"version":"3.49.0"},"reference-count":190,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The gasotransmitters nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), carbon monoxide (<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>), and hydrogen sulphide (H<jats:sub>2<\/jats:sub>S), long considered only toxicant, are produced in\u00a0vivo during the catabolism of common biological molecules and are crucial for a large variety of physiological processes. Mounting evidence is emerging that in poikilotherm vertebrates, as in mammals, they modulate the basal performance of the heart and the response to stress challenges. In this review, we will focus on teleost fish and amphibians to highlight the evolutionary importance in vertebrates of the cardiac control elicited by<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>and H<jats:sub>2<\/jats:sub>S, and the conservation of the intracellular cascades they activate. Although many gaps are still present due to discontinuous information, we will use examples obtained by studies from our and other laboratories to illustrate the complexity of the mechanisms that, by involving gasotransmitters, allow beat\u2010to\u2010beat, short\u2010, medium\u2010 and long\u2010term cardiac homoeostasis. By presenting the latest data, we will also provide a framework in which the peculiar morpho\u2010functional arrangement of the teleost and amphibian heart can be considered as a reference tool to decipher cardiac regulatory networks which are difficult to explore using more conventional vertebrates, such as mammals.<\/jats:p>","DOI":"10.1111\/apha.13035","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T21:52:43Z","timestamp":1516139563000},"source":"Crossref","is-referenced-by-count":18,"title":["<scp>NO<\/scp>,<scp>CO<\/scp>and H<sub>2<\/sub>S: What about gasotransmitters in fish and amphibian heart?"],"prefix":"10.1111","volume":"223","author":[{"given":"S.","family":"Imbrogno","sequence":"first","affiliation":[{"name":"Department of Biology, Ecology and Earth Sciences University of Calabria Arcavacata di Rende Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Filice","sequence":"additional","affiliation":[{"name":"Department of Biology, Ecology and Earth Sciences University of Calabria Arcavacata di Rende Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Cerra","sequence":"additional","affiliation":[{"name":"Department of Biology, Ecology and Earth Sciences University of Calabria Arcavacata di Rende Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Department of Biology, Ecology and Earth Sciences University of Calabria Arcavacata di Rende Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.03.003"},{"key":"e_1_2_16_6_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada S","year":"1991","journal-title":"Pharmacol Rev"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.10.006"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0510-x"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603768295249"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00324.2004"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2008.11.004"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.04.004"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-015-0949-x"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12170"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.027391"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01119"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2009.1189"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.05.206"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.a.195"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2012.04.003"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666141106114928"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2013.09.009"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.fp.2017.05.001"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2011.05.001"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(83)90442-5"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001670103"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19960601\/15)275:2\/3<162::AID-JEZ8>3.0.CO;2-B"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.38.1.99"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-57077-3_17"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.1.355"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.04.004"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.048140"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.10.1846"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90269-0"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.444"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.207381"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.081501.155952"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.657"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513341200"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80274-3"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2005.05.048"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007286602865"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01298-4"},{"key":"e_1_2_16_44_1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1242\/jeb.204.10.1719","article-title":"Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla","volume":"204","author":"Imbrogno S","year":"2001","journal-title":"J\u00a0Exp Biol"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao052011"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.08.012"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00468"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2004.07.008"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02595"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.045567"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2017.02.007"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.089292"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01488"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02519"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.05.027"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00883"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2010.12.008"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msq179"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-014-0877-1"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2005.12.007"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2007.10.004"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2013.03.005"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1139\/z96-134"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00353.2014"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600050052"},{"key":"e_1_2_16_66_1","first-page":"225","article-title":"Endothelium\u2010dependent responses in isolated blood vessels of lower vertebrates","volume":"23","author":"Miller VM","year":"1986","journal-title":"Blood Vessels"},{"key":"e_1_2_16_67_1","first-page":"H1856","article-title":"Capillary hydraulic conductivity is decreased by nitric oxide synthase inhibition","volume":"268","author":"Rumbaut RE","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15568.x"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.205.19.3093"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2479-6"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90810-9"},{"key":"e_1_2_16_72_1","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1242\/jeb.200.24.3109","article-title":"Endocardial endothelium in the avascular heart of the frog: morphology and role of nitric oxide","volume":"200","author":"Sys SU","year":"1997","journal-title":"J Exp Biol"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01235.2003"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.05.012"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(99)00072-8"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.04.031"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2007"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2423(07)01014-9"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568013043357536"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.05.005"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.2.H633"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12493"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00172.2008"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0318"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2016.12.030"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2015.12.008"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(03)00006-3"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2014.03.006"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2012.02389.x"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.025171"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200112761"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214995"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr023045"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000204350.44226.9a"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.01.012"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2466"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00407.2006"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00616.2011"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.03.008"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.008748"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.070367"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.2.748"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.3"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.1994"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1139\/y97-187"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90507.2008"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00274.2007"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.3.639"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00624.2002"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.4.R1087"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00174-X"},{"key":"e_1_2_16_113_1","first-page":"52","article-title":"Endothelium\u2010dependent and \u2010independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light","volume":"28","author":"Furchgott RF","year":"1991","journal-title":"Blood Vessels"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.13.8222"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/74680"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900301031"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.019141"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3000"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.136853"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142801"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.02.017"},{"key":"e_1_2_16_122_1","first-page":"OL1906","article-title":"Acute toxicity of a commercial glyphosate formulation on European sea bass juveniles (Dicentrarchus labrax): gene expressions of heme oxygenase\u20101 (ho\u20101), acetylcholinesterase (AChE) and aromatases (cyp19a and cyp19b)","volume":"59","author":"Prevot\u2010D'Alvise N","year":"2013","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_16_123_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.32604\/biocell.2008.32.259","article-title":"Heme metabolism enzymes are dynamically expressed during Xenopus embryonic development","volume":"32","author":"Shi J","year":"2008","journal-title":"Biocell"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00094.2016"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.04.006"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920007779815940"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22042"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03346-8"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2094"},{"key":"e_1_2_16_130_1","first-page":"208","article-title":"Inducible nitric oxide synthase and heme oxygenase\u20101 in rat heart: direct effect of chronic exposure to hypoxia","volume":"33","author":"Grilli A","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.05.013"},{"key":"e_1_2_16_132_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0022-3565(25)22706-9","article-title":"Induction of heart heme oxygenase\u20101 (HSP32) by hyperthermia: possible role in stress\u2010mediated elevation of cyclic 3\u2032:5\u2032\u2010guanosine monophosphate","volume":"271","author":"Ewing JF","year":"1994","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199703030-00045"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00671.2003"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-166454"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12811"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.11.005"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2010.04.002"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.107047"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053748"},{"key":"e_1_2_16_141_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1242\/jeb.55.3.683","article-title":"Respiratory and circulatory responses of rainbow trout larvae to carbon monoxide and to hypoxia","volume":"5","author":"Holeton GF","year":"1971","journal-title":"J Exp Biol"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.201.9.1461"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.221"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.130"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00087"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12765"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi801738j"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.097642"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05351.x"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/323269"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2894"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00034.2013"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00013.2002"},{"key":"e_1_2_16_157_1","first-page":"175","article-title":"Electrophysiological effects of hydrogen sulfide on pacemaker cells in sinoatrial nodes of rabbits","volume":"60","author":"Xu M","year":"2008","journal-title":"Sheng Li Xue Bao"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn140"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.01.007"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800700105"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20100003"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063291"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.03.005"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00419.2003"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.804"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00521.2009"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5930"},{"key":"e_1_2_16_168_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.010066"},{"key":"e_1_2_16_169_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00025.2008"},{"key":"e_1_2_16_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.01.019"},{"key":"e_1_2_16_171_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050102"},{"key":"e_1_2_16_172_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.920991"},{"key":"e_1_2_16_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-011-1280-5"},{"key":"e_1_2_16_174_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00088.2013"},{"key":"e_1_2_16_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071069"},{"key":"e_1_2_16_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4873"},{"key":"e_1_2_16_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw020"},{"key":"e_1_2_16_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053319"},{"key":"e_1_2_16_179_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202916109"},{"key":"e_1_2_16_180_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000855"},{"key":"e_1_2_16_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.021"},{"key":"e_1_2_16_182_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705929200"},{"key":"e_1_2_16_183_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00425.x"},{"key":"e_1_2_16_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-3127-5"},{"key":"e_1_2_16_185_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.1.221"},{"key":"e_1_2_16_186_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01057"},{"key":"e_1_2_16_187_1","doi-asserted-by":"publisher","DOI":"10.4172\/2368-0512.1000008"},{"key":"e_1_2_16_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.10.037"},{"key":"e_1_2_16_189_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00538.2011"},{"key":"e_1_2_16_190_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100763"},{"key":"e_1_2_16_191_1","series-title":"CRC Marine Science Series, 9","first-page":"129","volume-title":"The Physiology of Fishes","author":"Olson KR","year":"1998"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.13035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.13035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T21:52:26Z","timestamp":1751233946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.13035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":190,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/apha.13035"],"URL":"https:\/\/doi.org\/10.1111\/apha.13035","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,12]]},"article-number":"e13035"}}