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Conversely, reduced\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    bioavailability is a central feature during natural ageing and in many cardiovascular disorders, including hypertension. The inorganic anions nitrate and nitrite are endogenously formed after oxidation of\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    synthase (\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    )\u2010derived\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    and are also present in our daily diet. Knowledge accumulated over the past two decades has demonstrated that these anions can be recycled back to\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    and other bioactive nitrogen oxides via serial reductions that involve oral commensal bacteria and various enzymatic systems. Intake of inorganic nitrate, which is predominantly found in green leafy vegetables and beets, has a variety of favourable cardiovascular effects. As hypertension is a major risk factor of morbidity and mortality worldwide, much attention has been paid to the blood pressure reducing effect of inorganic nitrate. Here, we describe how dietary nitrate, via stimulation of the nitrate\u2010nitrite\u2010\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    pathway, affects various organ systems and discuss underlying mechanisms that may contribute to the observed blood pressure\u2010lowering effect.\n                  <\/jats:p>","DOI":"10.1111\/apha.13080","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T14:45:39Z","timestamp":1524667539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Mechanisms underlying blood pressure reduction by dietary inorganic nitrate"],"prefix":"10.1111","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-8729","authenticated-orcid":false,"given":"M.","family":"Carlstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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