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The <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> is integrated in the sympathoadrenal axis that helps the body maintain homoeostasis during both routine life and in acute stress conditions. This function is exquisitely controlled by the cerebral cortex and the hypothalamus. We propose the hypothesis that damage undergone by the brain during neurodegenerative diseases is also affecting the neurosecretory function of adrenal medullary <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s. In this context, we review here the following themes: (i) How the discharge of catecholamines is centrally and peripherally regulated at the sympathoadrenal axis; (ii) which are the intricacies of the amperometric techniques used to study the quantal release of single\u2010vesicle exocytotic events; (iii) which are the alterations of the exocytotic fusion pore so far reported, in <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s of mouse models of neurodegenerative diseases; (iv) how some proteins linked to neurodegenerative pathologies affect the kinetics of exocytotic events; (v) finally, we try to integrate available data into a hypothesis to explain how the centrally originated neurodegenerative diseases may alter the kinetics of single\u2010vesicle exocytotic events in peripheral adrenal medullary <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/apha.13090","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T19:24:34Z","timestamp":1525893874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Altered exocytosis in chromaffin cells from mouse models of neurodegenerative diseases"],"prefix":"10.1111","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-3330","authenticated-orcid":false,"given":"A. 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