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Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signalling network in islets involving 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>is being unravelled. With more than fourteen different 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>receptors expressed in human islets and receptor\u2010independent mechanisms in insulin\u2010producing \u03b2\u2010cells, our understanding of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>'s regulation of insulin secretion is increasing. It is now widely accepted that failure of the pancreatic \u03b2\u2010cell to release sufficient amounts of insulin is the main cause of type 2 diabetes (T2D), an ongoing global epidemic. In this context, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>signalling may be of importance. In fact, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>may serve an essential role in regulating the release of insulin and glucagon, the two main hormones that control glucose and lipid homoeostasis. In this review, we will discuss past and current understanding of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>'s role in the endocrine pancreas.<\/jats:p>","DOI":"10.1111\/apha.13101","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T16:57:26Z","timestamp":1527094646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Serotonergic regulation of insulin secretion"],"prefix":"10.1111","volume":"225","author":[{"given":"L. 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