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The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and electron microscopy, NMJ transmission by electrophysiological methods, protein analysis, and state of the art microsurgical techniques, in C57BL6, MuRF1KO and Thy\u20101 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that the SNS regulates motor nerve synaptic vesicle release, skeletal muscle transcriptome, muscle force generated by motor nerve activity, axonal neurofilament phosphorylation, myelin thickness, and myofibre subtype composition and CSA. The SNS also modulates the levels of postsynaptic membrane acetylcholine receptor by regulating the G\u03b1\n                      <jats:sub>i2<\/jats:sub>\n                      \u2010Hdac4\u2010Myogenin\u2010MuRF1pathway, which is prevented by the overexpression of the guanine nucleotide\u2010binding protein G\u03b1\n                      <jats:sub>i2<\/jats:sub>\n                      (Q205L), a constitutively active mutant G protein subunit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The SNS regulates NMJ transmission, maintains optimal G\u03b1\n                      <jats:sub>i2<\/jats:sub>\n                      expression, and prevents any increase in\n                      <jats:italic>Hdac4<\/jats:italic>\n                      ,\n                      <jats:italic>myogenin<\/jats:italic>\n                      ,\n                      <jats:italic>MuRF1,<\/jats:italic>\n                      and miR\u2010206. SNS ablation leads to upregulation of MuRF1, muscle atrophy, and downregulation of postsynaptic AChR. Our findings are relevant to clinical conditions characterized by progressive decline of sympathetic innervation, such as neurodegenerative diseases and aging.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.13195","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T11:20:55Z","timestamp":1538306455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability"],"prefix":"10.1111","volume":"225","author":[{"given":"Anna C. 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