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Epidemiological and clinical data show that AKI is linked to a wide range of distant organ injuries, with the lungs, heart, liver, and intestines representing the most clinically relevant affected organs. This distant organ injury during AKI predisposes patients to progression to multiple organ dysfunction syndrome and ultimately, death. The strongest direct evidence of distant organ injury occurring in AKI has been obtained from animal models. The identified mechanisms include systemic inflammatory changes, oxidative stress, increases in leucocyte trafficking and the activation of proapoptotic pathways. Understanding the pathways driving AKI\u2010induced distal organ injury are critical for the development and refinement of therapies for the prevention and attenuation of AKI\u2010related morbidity and mortality. The purpose of this review is to summarize both clinical and preclinical studies of AKI and its role in distant organ injury.<\/jats:p>","DOI":"10.1111\/apha.13357","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T08:08:48Z","timestamp":1564992528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Distant organ dysfunction in acute kidney injury"],"prefix":"10.1111","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-5052","authenticated-orcid":false,"given":"Faeq","family":"Husain\u2010Syed","sequence":"first","affiliation":[{"name":"Division of Nephrology, Pulmonology, and Critical Care Medicine, Department of Internal Medicine II University Hospital Giessen and Marburg Giessen Germany"},{"name":"Department of Nephrology, Dialysis and Transplantation, International Renal Research Institute of Vicenza (IRRIV) San Bortolo Hospital Vicenza 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