{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:40:32Z","timestamp":1783363232989,"version":"3.54.6"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Critical illness myopathy (CIM) represents a common consequence of modern intensive care, negatively impacting patient health and significantly increasing health care costs; however, there is no treatment available apart from symptomatic and supportive interventions. The chaperone co\u2010inducer BGP\u201015 has previously been shown to have a positive effect on the diaphragm in rats exposed to the intensive care unit (ICU) condition. In this study, we aim to explore the effects of BGP\u201015 on a limb muscle (soleus muscle) in response to the ICU condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sprague\u2010Dawley rats were subjected to the ICU condition for 5, 8 and 10\u00a0days and compared with untreated sham\u2010operated controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BGP\u201015 significantly improved soleus muscle fibre force after 5\u00a0days exposure to the ICU condition. This improvement was associated with the protection of myosin from post\u2010translational myosin modifications, improved mitochondrial structure\/biogenesis and reduced the expression of MuRF1 and Fbxo31 E3 ligases. At longer durations (8 and 10\u00a0days), BGP\u201015 had no protective effect when the hallmark of CIM had become manifest, that is, preferential loss of myosin. Unrelated to the effects on skeletal muscle, BGP\u201015 had a strong positive effect on survival compared with untreated animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BGP\u201015 treatment improved soleus muscle fibre and motor protein function after 5\u00a0days exposure to the ICU condition, but not at longer durations (8 and 10\u00a0days) when the preferential loss of myosin was manifest. Thus, long\u2010term CIM interventions targeting limb muscle fibre\/myosin force generation capacity need to consider both the post\u2010translational modifications and the loss of myosin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.13425","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T10:55:29Z","timestamp":1575456929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chaperone co\u2010inducer BGP\u201015 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model"],"prefix":"10.1111","volume":"229","author":[{"given":"Nicola","family":"Cacciani","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meishan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Akkad","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Backeus","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Hedstrom","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu P.","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4597-041X","authenticated-orcid":false,"given":"Jonas","family":"Bergquist","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department of Chemistry\u2013Biomedical Centre Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-035X","authenticated-orcid":false,"given":"Lars","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Clinical Neurophysiology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Biobehavioral Health The Pennsylvania State University University Park PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11500"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.09.024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1417-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84847-1_8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-8-242"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01105.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00066.Nordquist"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.202044"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00116.2011"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00123.2012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092622"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00026.2009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271973"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.277962"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-602"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.248724"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7099"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0110-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020558"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705799105"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0967"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10980"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00417"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.277962"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.199067"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00463.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.10.011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.04.023"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161213804143716"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-244210"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00049"},{"issue":"8","key":"e_1_2_8_34_1","first-page":"821","article-title":"Effect of furosemide and furosemide\u2010carbazochrome combination on exercise\u2010induced pulmonary hemorrhage in Standardbred racehorses","volume":"50","author":"Perez\u2010Moreno CI","year":"2009","journal-title":"Can Vet J"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12980"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00039.2012"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.02.009"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201302621"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070737"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12307"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2017.09.037"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275050"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx238"},{"issue":"8","key":"e_1_2_8_44_1","first-page":"1053","article-title":"Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta","volume":"4","author":"Grace MH","year":"2009","journal-title":"Nat Prod Commun"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/es9010515"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.44.27285"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.09.019"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.261"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.104.2.298"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00469.2003"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012845"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(88)57093-3"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012804"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(82)85020-9"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005614212575"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005614212575"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2009.07.003"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b05092"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.08.033"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01096.2012"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapha.13425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.13425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apha.13425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.13425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:57:41Z","timestamp":1693911461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.13425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/apha.13425"],"URL":"https:\/\/doi.org\/10.1111\/apha.13425","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"assertion":[{"value":"2019-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13425"}}