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However, accumulating experimental evidence has revealed the existence of nerves mediating vasodilatation, including perivascular nitrergic nerves (PNN), in a wide variety of mammalian species. Functioning of nitrergic vasodilator nerves is evidenced in several territories, including cerebral, mesenteric, pulmonary, renal, penile, uterine and cutaneous arteries. Nitric oxide (NO) is the main neurogenic vasodilator in cerebral arteries and acts as a counter\u2010regulatory mechanism for adrenergic vasoconstriction in other vascular territories. In the penis, NO relaxes the vascular and cavernous smooth muscles leading to penile erection. Furthermore, when interacting with other perivascular nerves, NO can act as a neuromodulator. PNN dysfunction is involved in the genesis and maintenance of vascular disorders associated with arterial and portal hypertension, diabetes, ageing, obesity, cirrhosis and hormonal changes. For example defective nitrergic function contributes to enhanced sympathetic neurotransmission, vasoconstriction and blood pressure in some animal models of hypertension. In diabetic animals and humans, dysfunctional nitrergic neurotransmission in the corpus cavernosum is associated with erectile dysfunction. However, in some vascular beds of hypertensive and diabetic animals, an increased PNN function has been described as a compensatory mechanism to the increased vascular resistance. The present review summarizes current understanding on the role of PNN in control of vascular tone, its alterations under different conditions and the associated mechanisms. The knowledge of these changes can serve to better understand the mechanisms involved in these disorders and help in planning new treatments.<\/jats:p>","DOI":"10.1111\/apha.13484","type":"journal-article","created":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T07:56:47Z","timestamp":1587887807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Nitrergic perivascular innervation in health and diseases: Focus on vascular tone regulation"],"prefix":"10.1111","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-2562","authenticated-orcid":false,"given":"Fabiano E.","family":"Xavier","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia Centro de Bioci\u00eancias Universidade Federal de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"17","article-title":"The crosstalk between autonomic nervous system and blood vessels","volume":"10","author":"Sheng Y","year":"2018","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1464-2_7"},{"key":"e_1_2_8_4_1","first-page":"515","article-title":"Ultrastructure of sympathetic axons and their structural relationship with vascular smooth muscle","volume":"193","author":"Luff SE","year":"1986","journal-title":"Anatomy Embryol (Berlim)"},{"key":"e_1_2_8_5_1","first-page":"67","article-title":"The changing face of autonomic neurotransmission. 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