{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:37:55Z","timestamp":1788827875730,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["CVON2014\u201002 ENERGISE"],"award-info":[{"award-number":["CVON2014\u201002 ENERGISE"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["951 05007"],"award-info":[{"award-number":["951 05007"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Heat exposure has been indicated to positively affect glucose metabolism. An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been previously suggested. Here, we performed an intervention study exploring the effect of passive heat acclimation (PHA) on glucose metabolism and intracellular (a) HSP72 concentrations in overweight humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven non\u2010diabetic overweight (BMI 27\u201035 kg\/m<jats:sup>2<\/jats:sup>) participants underwent 10 consecutive days of PHA (4\u20106 h\/day, 34.4\u00a0\u00b1\u00a00.2\u00b0C, 22.8\u00a0\u00b1\u00a02.7%RH). Before and after PHA, whole\u2010body insulin sensitivity was assessed using a one\u2010step hyperinsulinaemic\u2010euglycaemic clamp, skeletal muscle biopsies were taken to measure intracellular iHSP72, energy expenditure and substrate oxidation were measured using indirect calorimetry and blood samples were drawn to assess markers of metabolic health. Thermophysiological adaptations were measured during a temperature ramp protocol before and after PHA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite a lack of change in iHSP72, 10\u00a0days of PHA reduced basal (9.7\u00a0\u00b1\u00a01.4 pre\u2010 vs 8.4\u00a0\u00b1\u00a02.1 \u03bcmol \u00b7 kg<jats:sup>\u20131<\/jats:sup> \u00b7 min<jats:sup>\u20131<\/jats:sup> post\u2010PHA, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.038) and insulin\u2010stimulated (2.1\u00a0\u00b1\u00a00.9 pre\u2010 vs 1.5\u00a0\u00b1\u00a00.8 \u03bcmol \u00b7 kg<jats:sup>\u20131<\/jats:sup> \u00b7 min<jats:sup>\u20131<\/jats:sup> post\u2010PHA, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) endogenous glucose production (EGP) and increased insulin suppression of EGP (78.5\u00a0\u00b1\u00a09.7% pre\u2010 vs 83.0\u00a0\u00b1\u00a07.9% post\u2010PHA, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.028). Consistently, fasting plasma glucose (6.0\u00a0\u00b1\u00a00.5 pre\u2010 vs 5.8\u00a0\u00b1\u00a00.4 mmol\/L post\u2010PHA, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013) and insulin concentrations (97\u00a0\u00b1\u00a055 pre\u2010 vs 84\u00a0\u00b1\u00a049 pmol\/L post\u2010PHA, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026) decreased significantly. Moreover, fat oxidation increased, and free fatty acids as well as cholesterol concentrations and mean arterial pressure decreased after PHA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that PHA for 10\u00a0days improves glucose metabolism and enhances fat metabolism, without changes in iHSP72. Further exploration of the therapeutic role of heat in cardio\u2010metabolic disorders should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.13488","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T19:43:57Z","timestamp":1588448637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Passive exposure to heat improves glucose metabolism in overweight humans"],"prefix":"10.1111","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-1277","authenticated-orcid":false,"given":"Hannah","family":"Pallubinsky","sequence":"first","affiliation":[{"name":"Department of Nutrition and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Maastricht the 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