{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:20:26Z","timestamp":1780518026328,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006680","name":"Takeda Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Skeletal muscles are distributed throughout the body, presenting a variety of sizes, shapes and functions. Here, we examined whether muscle regeneration and atrophy occurred homogeneously throughout the body in mouse models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute muscle regeneration was induced by a single intramuscular injection of cardiotoxin in adult mice. Chronic muscle regeneration was assessed in <jats:italic>mdx<\/jats:italic> mice. Muscle atrophy in different muscles was evaluated by cancer cachexia, ageing and castration mouse models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that, in the cardiotoxin\u2010injected acute muscle injury model, head muscles slowly regenerated, while limb muscles exhibited a rapid regeneration and even overgrowth. This overgrowth was also observed in limb muscles alone (but not in head muscles) in <jats:italic>mdx<\/jats:italic> mice as chronic injury models. We described the body region\u2013specific decline in the muscle mass in muscle atrophy models: cancer cachexia\u2010induced, aged and castrated mice. The positional identities, including gene expression profiles and hormone sensitivity, were robustly preserved in the ectopically engrafted satellite cell\u2010derived muscles in the castrated model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that positional identities in muscles should be considered for the development of efficient regenerative therapies for muscle weakness, such as muscular dystrophy and age\u2010related sarcopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.13553","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T10:52:38Z","timestamp":1599043958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The body region specificity in murine models of muscle regeneration and atrophy"],"prefix":"10.1111","volume":"231","author":[{"given":"Kiyoshi","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Muscle Development and Regeneration Institute of Molecular Embryology and Genetics Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Muscle Development and Regeneration Institute of Molecular Embryology and Genetics Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Seko","sequence":"additional","affiliation":[{"name":"Department of Muscle Development and Regeneration Institute of Molecular Embryology and Genetics Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Muscle Development and Regeneration Institute of Molecular Embryology and Genetics Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-7507","authenticated-orcid":false,"given":"Yusuke","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Muscle Development and Regeneration Institute of Molecular Embryology and Genetics Kumamoto University Kumamoto 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