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It is well established that circulating ghrelin levels are closely associated with feeding patterns, rising strongly before a meal and lowering upon food intake. However, the mechanisms underlying the modulation of ghrelin secretion are not fully understood. The purpose of this review is to discuss current knowledge on the circadian oscillation of circulating ghrelin levels, the neural mechanisms stimulating fasting ghrelin levels and peripheral mechanisms modulating postprandial ghrelin levels. Furthermore, the therapeutic potential of targeting the ghrelin pathway is discussed in the context of the treatment of various metabolic disorders, including obesity, type 2 diabetes, diabetic gastroparesis and Prader\u2010Willi syndrome. Moreover, eating disorders including anorexia nervosa, bulimia nervosa and binge\u2010eating disorder are also discussed.<\/jats:p>","DOI":"10.1111\/apha.13588","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T06:46:31Z","timestamp":1606632391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The regulation of gastric ghrelin secretion"],"prefix":"10.1111","volume":"231","author":[{"given":"Maria","family":"Nunez\u2010Salces","sequence":"first","affiliation":[{"name":"Vagal Afferent Research Group Adelaide Medical School The University of Adelaide Adelaide SA Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health Adelaide Medical School The University of Adelaide Adelaide SA Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme South Australian Health &amp; Medical Research Institute (SAHMRI) Adelaide 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