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Sustained activation of cardiac O\u2010GlcNAcylation is frequently associated with alterations in cellular metabolism, leading to detrimental effects on cardiovascular function. This is particularly true during conditions such as diabetes, hypertension, cardiac remodelling, heart failure and arrhythmogenesis. Paradoxically, transient elevation of cardiac protein O\u2010GlcNAcylation can also exert beneficial effects in the heart. There is compelling evidence to suggest that a complex interaction between O\u2010GlcNAcylation and phosphorylation also exists in the heart. Beyond direct functional consequences on cardiomyocytes, O\u2010GlcNAcylation also acts indirectly by altering the function of transcription factors that affect downstream signalling. This review focuses on the potential cardioprotective role of protein O\u2010GlcNAcylation during ischaemia\u2010reperfusion injury, the deleterious consequences of chronically elevated O\u2010GlcNAc levels, the interplay between O\u2010GlcNAcylation and phosphorylation in the cardiomyocytes and the effects of O\u2010GlcNAcylation on other major non\u2010myocyte cell types in the heart.<\/jats:p>","DOI":"10.1111\/apha.13696","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T10:53:41Z","timestamp":1622458421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Protein O\u2010GlcNAcylation in the heart"],"prefix":"10.1111","volume":"233","author":[{"given":"Yann Huey","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Medicine and HeartOtago University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidinma 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