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Methods: 16 participants (7 females) visited the laboratory on 7 separate occasions: (1) three 6\u2010minutes moderate\u2010intensity cycling exercise bouts proceeded by a ramp incremental test; (2\u20103) 30\u2010minutes constant power output (PO) exercise bout to determine the maximal lactate steady state (MLSS); (4\u20107) constant\u2010PO exercise bouts to task failure (TTF), pseudorandomized order, at (i) 15% below the PO at MLSS; (ii) 10\u00a0W below MLSS; (iii) MLSS; (iv) 10\u00a0W above MLSS (first intensity and randomized order thereafter). Neuromuscular fatigue was characterized by isometric maximal voluntary contractions and femoral nerve electrical stimulation of knee extensors to measure peripheral fatigue at baseline, at min 5, 10, 20, 30 and TTF. Pulmonary oxygen uptake (V\u0307O<jats:sub>2<\/jats:sub>) was continuously recorded during the constant\u2010PO bouts and V\u0307O<jats:sub>2SC<\/jats:sub> was characterized based on each individual V\u0307O<jats:sub>2<\/jats:sub> kinetics during moderate transitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The development of V\u0307O<jats:sub>2SC<\/jats:sub> and peripheral fatigue were correlated across time (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>adj<\/jats:italic> range of 0.64\u20100.80) and amongst each exercise intensity (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>adj<\/jats:italic> range of 0.26\u20100.30) (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Also, TTF was correlated with V\u0307O<jats:sub>2SC<\/jats:sub> and neuromuscular fatigue parameters (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>adj<\/jats:italic> range of 0.52\u20100.82, all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The V\u0307O<jats:sub>2SC<\/jats:sub> and peripheral fatigue development are correlated throughout the exercise in a time\u2010 and intensity\u2010dependent manner, suggesting that the V\u0307O<jats:sub>2SC<\/jats:sub> may depend on muscle fatigue even if the mechanisms of reduced contractile function are different amongst intensities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.13776","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T13:10:56Z","timestamp":1641388256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effects of exercise intensity and duration on the relationship between the slow component of V\u0307O<sub>2<\/sub> and peripheral fatigue"],"prefix":"10.1111","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0346-7007","authenticated-orcid":false,"given":"Rafael","family":"de Almeida Azevedo","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Keir","sequence":"additional","affiliation":[{"name":"School of Kinesiology The University of Western Ontario London Ontario Canada"},{"name":"Department of Medicine Toronto General Hospital Research Institute University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Forot","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"The Sport Performance Reserch Group National Ski\u2010Nordic Center Premanon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Iannetta","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-0762","authenticated-orcid":false,"given":"Guillaume Y.","family":"Millet","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"Inter\u2010University Laboratory of Human Movement Biology UJM\u2010Saint\u2010Etienne Univ Lyon Saint\u2010Etienne France"},{"name":"Institut Universitaire de France (IUF) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-6453","authenticated-orcid":false,"given":"Juan M.","family":"Murias","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University 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