{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:05:07Z","timestamp":1791986707415,"version":"4.4.0"},"reference-count":171,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0057507"],"award-info":[{"award-number":["NNF19OC0057507"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Voltage\u2010gated potassium (K<jats:sub>v<\/jats:sub>) channels play an important role in the repolarization of a variety of excitable tissues, including in the cardiomyocyte and the pancreatic beta cell. Recently, individuals carrying loss\u2010of\u2010function (LoF) mutations in <jats:italic>KCNQ1<\/jats:italic>, encoding K<jats:sub>v<\/jats:sub>7.1, and <jats:italic>KCNH2<\/jats:italic> (hERG), encoding K<jats:sub>v<\/jats:sub>11.1, were found to exhibit post\u2010prandial hyperinsulinaemia and episodes of hypoglycaemia. These LoF mutations also cause the cardiac disorder long QT syndrome (LQTS), which can be aggravated by hypoglycaemia. Interestingly, patients with LQTS also have a higher burden of diabetes compared to the background population, an apparent paradox in relation to the hyperinsulinaemic phenotype, and <jats:italic>KCNQ1<\/jats:italic> has been identified as a type 2 diabetes risk gene. This review article summarizes the involvement of delayed rectifier K<jats:sup>+<\/jats:sup> channels in pancreatic beta cell function, with emphasis on K<jats:sub>v<\/jats:sub>7.1 and K<jats:sub>v<\/jats:sub>11.1, using the cardiomyocyte for context. The functional and clinical consequences of LoF mutations and polymorphisms in these channels on blood glucose homeostasis are explored using evidence from pre\u2010clinical, clinical and genome\u2010wide association studies, thereby evaluating the link between LQTS, hyperinsulinaemia and type 2 diabetes.<\/jats:p>","DOI":"10.1111\/apha.13781","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T13:43:27Z","timestamp":1641476607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Celebrities in the heart, strangers in the pancreatic beta cell: Voltage\u2010gated potassium channels K<sub>v<\/sub>7.1 and K<sub>v<\/sub>11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes"],"prefix":"10.1111","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-8581","authenticated-orcid":false,"given":"Anniek F.","family":"Lubberding","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-4017","authenticated-orcid":false,"given":"Christian R.","family":"Juhl","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil Z.","family":"Skovh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-4910","authenticated-orcid":false,"given":"J\u00f8rgen K.","family":"Kanters","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-9273","authenticated-orcid":false,"given":"Thomas","family":"Mandrup\u2010Poulsen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-0252","authenticated-orcid":false,"given":"Signe S.","family":"Torekov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1987.67.3.1054"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/384080a0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1159-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1454"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024279"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2019-001161"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.208"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.207"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7145139"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510790103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081867"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.09.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.02.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183754"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118308"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.1.227"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0991"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410201"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.274209"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.150706.112"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11320"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.184341"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00784.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.114.6.759"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.10"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb02331.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00978"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116269"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5360.69"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2011"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-16712-6_358"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.005"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.3.597"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0039"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.07.010"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205532200"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00054.2005"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.491654"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-0788"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0991"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.199083"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1170"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002703"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.102"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121669"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.03.083"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1479-2"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.4161\/19382014.2014.962386"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002100100410"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00187"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0810"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90452-8"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-0513-x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0077com"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.040659"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068740"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.005"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001218R"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00031.2005"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962019"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00504"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00285.x"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2005"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1376"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/384024a0"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224600"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur245"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-338"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601347"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.89"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066843"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105514"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00282.2011"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-3-1646"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/349077a0"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00588.x"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00365.2003"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(02)00307-3"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408344200"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0476-7"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0855-8"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-6478-3"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003723"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.03.003"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.210244497"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04710"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01572"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00472-X"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002383"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004517"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1231-2"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0637-y"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0416"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0640-3"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1494"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000847"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022353"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0454"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt399"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2897"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu248"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10531"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175681"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0047-6"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0332-4"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2263-3"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2019.0163"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.609"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2383"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3908-5"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3943"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04951-w"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0241-6"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09572-5"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2172-y"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12828"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0732"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1150"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0246"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1516"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032148"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005872"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1138"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1589"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08625"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103394"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-181"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002956"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1767"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.166"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1053\/sp.2000.6366"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2017-104919"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422104112"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00138"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05185-6"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2012.16"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091790"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.03.014"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199708)14:8<648::AID-DIA418>3.0.CO;2-1"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00528.x"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2013.37.3.190"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00750111"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i10.488"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0468"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211044200"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0232"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP09260.CR"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.6.463"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2016.46.6.747"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.24.3.171"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.04.034"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0967-1"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051345"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.018"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.12.016"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.05.012"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0779-8"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0b013e31827f174c"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183055"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13085"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188211010057"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125175"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90677-5"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00753-2"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab006"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-018-0602-2"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/797548"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2018.39.3"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8847"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028198"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.13781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apha.13781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.13781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:44:05Z","timestamp":1692989045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.13781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,22]]},"references-count":171,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/apha.13781"],"URL":"https:\/\/doi.org\/10.1111\/apha.13781","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,22]]},"assertion":[{"value":"2021-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13781"}}