{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:13:46Z","timestamp":1791728026156,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cardiac surgery requiring cardiopulmonary bypass (CPB) can result in renal and cerebral injury. Intraoperative tissue hypoxia could contribute to such organ injury. Hypothermia, however, may alleviate organ hypoxia. Therefore, we tested whether moderate hypothermia (30\u00b0C) improves cerebral and renal tissue perfusion and oxygenation during ovine CPB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten sheep were studied while conscious, under stable anesthesia, and during 3\u00a0h of CPB. In a randomized within\u2010animal cross\u2010over design, five sheep commenced CPB at a target body temperature of 30\u00b0C (moderate hypothermia). After 90\u2009min, the body temperature was increased to 36\u00b0C (standard procedure). The remaining five sheep were randomized to the opposite order of target body temperature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the standard procedure, moderately hypothermic CPB reduced renal oxygen delivery (\u221234.8%\u2009\u00b1\u200919.6%,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and renal oxygen consumption (\u221242.7%\u2009\u00b1\u200935.2%,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Nevertheless, moderately hypothermic CPB did not significantly alter either renal cortical or medullary tissue PO<jats:sub>2<\/jats:sub>. Moderately hypothermic CPB also did not significantly alter cerebral perfusion, cerebral tissue PO<jats:sub>2<\/jats:sub>, or cerebral oxygen saturation compared with the standard procedure. Compared with the anesthetized state, the standard procedure reduced renal medullary PO<jats:sub>2<\/jats:sub>(\u221221.0\u2009\u00b1\u200913.8\u2009mmHg,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.014) and cerebral oxygen saturation (65.0%\u2009\u00b1\u20097.0% to 55.4%\u2009\u00b1\u20099.6%,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022) but did not significantly alter either renal cortical or cerebral PO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ovine experimental CPB leads to renal medullary tissue hypoxia. Moderately hypothermic CPB did not improve cerebral or renal tissue oxygenation. In the kidney, this is probably because renal tissue oxygen consumption is matched by reduced renal oxygen delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.13860","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T17:48:49Z","timestamp":1658425729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Influence of moderate hypothermia on renal and cerebral haemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep"],"prefix":"10.1111","volume":"236","author":[{"given":"Alemayehu H.","family":"Jufar","sequence":"first","affiliation":[{"name":"Pre\u2010Clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health University of Melbourne Melbourne Victoria Australia"},{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology Monash University Melbourne Victoria 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