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Disruption of circadian rhythms has been associated with several metabolic diseases. In this review, we focus on liver as a major metabolic tissue and one of the most well\u2010studied organs with regard to circadian regulation. We summarize current knowledge about the role of local and systemic clocks and rhythms in regulating biological functions of the liver. We discuss how the disruption of circadian rhythms influences the development of non\u2010alcoholic fatty liver disease (NAFLD) and non\u2010alcoholic steatohepatitis (NASH). We also critically evaluate whether NAFLD\/NASH may in turn result in chronodisruption. The last chapter focuses on potential roles of the clock system in prevention and treatment of NAFLD\/NASH and the interaction of current NASH drug candidates with liver circadian rhythms and clocks. It becomes increasingly clear that paying attention to circadian timing may open new avenues for the optimization of NAFLD\/NASH therapies and provide interesting targets for prevention and treatment of these increasingly prevalent disorders.<\/jats:p>","DOI":"10.1111\/apha.13915","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:14:39Z","timestamp":1672877679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The role of the circadian clock in the development, progression, and treatment of non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5209-0835","authenticated-orcid":false,"given":"Leonardo Vinicius Monteiro","family":"de Assis","sequence":"first","affiliation":[{"name":"Institute of Neurobiology, Center of Brain Behavior &amp; Metabolism University of L\u00fcbeck  L\u00fcbeck 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