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Therefore, loss of cadherin\u2010mediated adhesion causes various disorders, including vascular inflammation and desmosome\u2010related diseases such as the autoimmune blistering skin dermatosis pemphigus and arrhythmogenic cardiomyopathy. Mechanisms regulating cadherin\u2010mediated binding contribute to the pathogenesis of diseases and may also be used as therapeutic targets. Over the last 30\u2009years, cyclic adenosine 3\u2032,5\u2032\u2010monophosphate (cAMP) has emerged as one of the master regulators of cell adhesion in endothelium and, more recently, also in epithelial cells as well as in cardiomyocytes. A broad spectrum of experimental models from vascular physiology and cell biology applied by different generations of researchers provided evidence that not only cadherins of endothelial adherens junctions (AJ) but also desmosomal contacts in keratinocytes and the cardiomyocyte intercalated discs are central targets in this scenario. The molecular mechanisms involve protein kinase A\u2010 and exchange protein directly activated by cAMP\u2010mediated regulation of Rho family GTPases and S665 phosphorylation of the AJ and desmosome adaptor protein plakoglobin. In line with this, phosphodiesterase 4 inhibitors such as apremilast have been proposed as a therapeutic strategy to stabilize cadherin\u2010mediated adhesion in pemphigus and may also be effective to treat other disorders where cadherin\u2010mediated binding is compromised.<\/jats:p>","DOI":"10.1111\/apha.14006","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T09:59:56Z","timestamp":1685181596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<scp>cAMP<\/scp>\n                    : A master regulator of cadherin\u2010mediated binding in endothelium, epithelium and myocardium"],"prefix":"10.1111","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-7595","authenticated-orcid":false,"given":"Franziska","family":"Vielmuth","sequence":"first","affiliation":[{"name":"Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine LMU Munich  Munich 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