{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:12:25Z","timestamp":1770271945864,"version":"3.49.0"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T00:00:00Z","timestamp":1694217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL144528"],"award-info":[{"award-number":["HL144528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000918","name":"New York Community Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review outlines the features of tandem regulation of glomerular microcirculation by autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points of cooperation exist between autoregulatory and distributional mechanisms. Mutual interactions between myogenic and tubuloglomerular feedback (TGF) mechanisms regulating the inflow are briefly discussed. In addition to this, TGF operation involving purinergic, autocoid, and NO signaling affects, however, not only afferent arteriolar tone, but mesangial cell tone as well. The latter reversibly reconfigures the distribution of blood flow between the shorter and longer pathways in the glomerular tuft. I advance a hypothesis that blood flow in these pathways spontaneously alternates, and mesangial cell tonicity serves as a rheostatic shift between them. Furthermore, humoral messengers from macula densa cells, themselves dependent on myogenic mechanisms, fine\u2010tune the secretion of renin and, subsequently, the local, intrarenal generation of angiotensin II, which, in turn, provides additional vasomotor signaling to glomerular capillaries through changing the tone of mesangial cells. This complex regulatory network may partially explain the phenomenon of renal functional reserve, as well as suggest implications for changes in renal function during pregnancy, early diabetes mellitus, and acute kidney injury.<\/jats:p>","DOI":"10.1111\/apha.14048","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:08:31Z","timestamp":1694243311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Glomerular microcirculation: Implications for diabetes, preeclampsia, and kidney injury"],"prefix":"10.1111","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-4469","authenticated-orcid":false,"given":"Michael S.","family":"Goligorsky","sequence":"first","affiliation":[{"name":"Department of Medicine New York Medical College at the Touro University  Valhalla New York USA"},{"name":"Department of Pharmacology New York Medical College at the Touro University  Valhalla New York USA"},{"name":"Department of Physiology New York Medical College at the Touro University  Valhalla New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.271"},{"key":"e_1_2_6_3_1","first-page":"R1153","article-title":"Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms","volume":"290","author":"Loutzenhaiser R","year":"2006","journal-title":"Am J Physiol: Regul"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00484.2018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022030354"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.770450"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87343"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071829"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581175"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1988.tb08394.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1993.tb09503.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0736323100"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00425.2005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00721.2012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00356.2001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00546.2020"},{"key":"e_1_2_6_19_1","first-page":"102","article-title":"Ion channels in mesangial cells: function, malfunction, or fiction","volume":"20","author":"Ma R","year":"2005","journal-title":"Phys Ther"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2022"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00268.2005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006091067"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006218200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1115-x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.264.3.F427"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00287.2004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1998.2139"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001511"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1994.267.1.F160"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00164.2004"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.264.1.F166"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V461275"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.2.357"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-2862(73)80005-6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.4.826"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.266.5.H1822"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-011-0064-4"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-190207"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007231"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13941"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36763"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.566273"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000412787"},{"issue":"3","key":"e_1_2_6_44_1","first-page":"F562","article-title":"Three\u2010dimensional reconstructed glomerular capillary network: blood flow distribution and local filtration","volume":"263","author":"Remuzzi A","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77211-x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00566.2017"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13592"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1977.232.3.F215"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1984.246.6.F897"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2009"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142238"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020070969"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00461.2015"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.3934\/molsci.2016.3.426"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091144"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011312"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90873-2"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1986.250.4.F613"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00237.2020"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0740011"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2020.07.006"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2016-1065"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.25130"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020070969"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853127"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00202.2020"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.872918"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.10.037"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00185.2007"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01145-4"},{"key":"e_1_2_6_71_1","first-page":"379","article-title":"Renal function studies in acute tubular necrosis","volume":"9","author":"Bull G","year":"1950","journal-title":"Clin Sci"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-89-21917"},{"key":"e_1_2_6_73_1","volume-title":"Studies of the Renal Circulation","author":"Trueta J","year":"1947"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.4749"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.14048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:39:22Z","timestamp":1698309562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.14048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,9]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/apha.14048"],"URL":"https:\/\/doi.org\/10.1111\/apha.14048","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,9]]},"assertion":[{"value":"2023-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14048"}}