{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:29:16Z","timestamp":1792517356328,"version":"4.5.0"},"reference-count":197,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","award":["10073099"],"award-info":[{"award-number":["10073099"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sarcopenia lowers the quality\u2010of\u2010life for millions of people across the world, as accelerated loss of skeletal muscle mass and function contributes to both age\u2010 and disease\u2010related frailty. Physical activity remains the only proven therapy for sarcopenia to date, but alternatives are much sought after to manage this progressive muscle disorder in individuals who are unable to exercise. Mitochondria have been widely implicated in the etiology of sarcopenia and are increasingly suggested as attractive therapeutic targets to help restore the perturbed balance between protein synthesis and breakdown that underpins skeletal muscle atrophy. Reviewing current literature, we note that mitochondrial bioenergetic changes in sarcopenia are generally interpreted as intrinsic dysfunction that renders muscle cells incapable of making sufficient ATP to fuel protein synthesis. Based on the reported mitochondrial effects of therapeutic interventions, however, we argue that the observed bioenergetic changes may instead reflect an adaptation to pathologically decreased energy expenditure in sarcopenic muscle. Discrimination between these mechanistic possibilities will be crucial for improving the management of sarcopenia.<\/jats:p>","DOI":"10.1111\/apha.14107","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T03:55:33Z","timestamp":1706846133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Mitochondrial involvement in sarcopenia"],"prefix":"10.1111","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-9943","authenticated-orcid":false,"given":"Charles","family":"Affourtit","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0699-104X","authenticated-orcid":false,"given":"Jane E.","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00516-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31138-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2015.04.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.09.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.11.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S410834"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.743710"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1137371"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00840-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8859719"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04253-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0062-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12783"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuad084"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.09.026"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1139-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2018.1439004"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"65","article-title":"Impaired muscle energy metabolism in uremia as monitored by 31P\u2010NMR","volume":"33","author":"Nishida A","year":"1991","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006802602497"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10040588"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10010031"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04369-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01883"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-023-01022-z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020249"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315039"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115664"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12839"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.01.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182667c2e"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-013-9583-2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.892749"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.016"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101966"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11050687"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36618"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434040-00002"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-2395-3-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3165396"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114310"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02737-1"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.02.021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00220-0"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.09.012"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/830257"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.024"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00321.2016"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.11.006"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.02.015"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311401"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48019-2"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5837"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.07.025"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00208-1"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00133.2007"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11041509"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328352b4c2"},{"issue":"4","key":"e_1_2_9_60_1","first-page":"405","article-title":"Sarcopenia in chronic kidney disease: focus on advanced glycation end products as mediators and markers of oxidative stress","volume":"9","author":"Dozio E","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00418.2001"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.964130"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153815"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt107"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00422"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050716"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.002"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00388.2021"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-272666"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2640fje"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.07.008"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3120163"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.04.286"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4246"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00203.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9442-6"},{"issue":"3","key":"e_1_2_9_77_1","first-page":"218","article-title":"Effect of chronic uraemia on skeletal muscle metabolism in man","volume":"8","author":"Thompson CH","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.05020163"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.01.006"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13552"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010037"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0195"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.067314"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1725"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12307"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2017.11.03"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.07.015"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0533"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138212"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101617"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.03.019"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0566-y"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20082055"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000213Y.0000000077"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.12.013"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002579"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.33594\/000000594"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.11.032"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.00246.x"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.279174"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2016.06.006"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00871.2015"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.6.2033"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01088"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.1888"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.6.534"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3983"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1076\/apab.104.2.129.12878"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.021"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13216"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000192"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.069633"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14722"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103113"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2019.1615556"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1196426"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44329-6"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11556-020-00243-9"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1261-3"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.09.011"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.09.002"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000605"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000465"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14526"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.1663"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0251-4"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00486"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/sports9090127"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00086.2011"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3081"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-012-9408-1"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901936RR"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.25.608"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.10.011"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1530\/endoabs.63.p98"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2019.11.004"},{"key":"e_1_2_9_138_1","first-page":"948","article-title":"Antioxidant role of vitamin D and its correlation with vitamin D deficiency in adults: a systematic review","volume":"5","author":"Alamir T","year":"2021","journal-title":"Int J Med Dev Ctries"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2121231"},{"issue":"9","key":"e_1_2_9_140_1","first-page":"306","article-title":"The anti\u2010inflammatory and antioxidant properties of n\u20103 PUFAs: their role in cardiovascular protection","volume":"8","author":"Oppedisano F","year":"2020","journal-title":"Biomedicine"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1928-1_28"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI939"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00051-7"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaa011"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27543"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1139\/H09-012"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e318292f3d5"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu103"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.04.007"},{"issue":"3","key":"e_1_2_9_150_1","first-page":"118","article-title":"Protein\u2014which is best?","volume":"3","author":"Hoffman JR","year":"2004","journal-title":"J Sports Sci Med"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-342"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00242.2011"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.09.002"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-015-2109-8"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.013"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.264S"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200109"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.153916"},{"issue":"1","key":"e_1_2_9_159_1","first-page":"1","article-title":"Branched chain amino acids","volume":"81","author":"Neinast M","year":"2018","journal-title":"Annu Rev Physiol"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12532"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.207S"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.1.43"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.2.E394"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.5.1744"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.3.E514"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.1.E99"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00340.2016"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903485106"},{"key":"e_1_2_9_169_1","first-page":"407","article-title":"Pharmacological therapy of sarcopenia: past, present and future","volume":"15","author":"Iolascon G","year":"2018","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15173854"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.4235\/agmr.19.0028"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00370.2002"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00502.2001"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0741"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13058"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2020.27.3.151"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt187"},{"issue":"11","key":"e_1_2_9_178_1","first-page":"5","article-title":"The hormonal fountains of youth: myth or reality?","volume":"28","author":"Kim MJ","year":"2005","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2016.1208168"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.748031"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-014-0159-5"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03917-0"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(99)00069-1"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707288"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220830112408"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082089"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122657"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000250"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122588"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.861622"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02508-9"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00473.2019"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.12.031"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-023-02326-3"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.03.079"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21539-y"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974\u2010023\u201009643\u20107"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13153"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.14107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T23:02:08Z","timestamp":1738969328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.14107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":197,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/apha.14107"],"URL":"https:\/\/doi.org\/10.1111\/apha.14107","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"2023-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14107"}}