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WAT transcriptomes showed evidence of reduced adipogenesis, and, in agreement, we found low levels of circulating adiponectin. To preserve adipogenesis and restore adiponectin levels, we treated mice with the PPAR\u2010\u03b3 agonist, rosiglitazone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rosiglitazone treatment increased serum adiponectin levels, delayed weight loss, and preserved skeletal muscle and adipose tissue mass, as compared to vehicle\u2010treated mice. The preservation of muscle mass with rosiglitazone was associated with increases in AMPK and AKT activity. Similarly, activation of the adiponectin receptors in muscle cells increased AMPK activity, anabolic signaling, and protein synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that PPAR\u2010\u03b3 agonists may be a useful adjuvant therapy to preserve tissue mass in lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.14167","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T04:40:14Z","timestamp":1716439214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer"],"prefix":"10.1111","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-4279","authenticated-orcid":false,"given":"Henning 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