{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:36Z","timestamp":1787013876114,"version":"build-2736575974"},"reference-count":135,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Calcineurin, protein phosphatase 2B (PP2B) or protein phosphatase 3 (PP3), is a calcium\u2010dependent serine\/threonine protein phosphatase. Calcineurin is widely expressed in the kidney and regulates renal Na\n                    <jats:sup>+<\/jats:sup>\n                    and K\n                    <jats:sup>+<\/jats:sup>\n                    transport. In the thick ascending limb, calcineurin plays a role in inhibiting NKCC2 function by promoting the dephosphorylation of the cotransporter and an intracellular sorting receptor, called sorting\u2010related\u2010receptor\u2010with\u2010A\u2010type repeats (SORLA), is involved in modulating the effect of calcineurin on NKCC2. Calcineurin also participates in regulating thiazide\u2010sensitive NaCl\u2010cotransporter (NCC) in the distal convoluted tubule. The mechanisms by which calcineurin regulates NCC include directly dephosphorylation of NCC, regulating Kelch\u2010like\u20103\/CUL3 E3 ubiquitin\u2013ligase complex, which is responsible for WNK (with\u2010no\u2010lysin\u2010kinases) ubiquitination, and inhibiting Kir4.1\/Kir5.1, which determines NCC expression\/activity. Finally, calcineurin is also involved in regulating ROMK (Kir1.1) channels in the cortical collecting duct and Cyp11 2 expression in adrenal zona glomerulosa. In summary, calcineurin is involved in the regulation of NKCC2, NCC, and inwardly rectifying K\n                    <jats:sup>+<\/jats:sup>\n                    channels in the kidney, and it also plays a role in modulating aldosterone synthesis in adrenal gland, which regulates epithelial\u2010Na\n                    <jats:sup>+<\/jats:sup>\n                    \u2010channel expression\/activity. Thus, application of calcineurin inhibitors (CNIs) is expected to abrupt calcineurin\u2010mediated regulation of transepithelial Na\n                    <jats:sup>+<\/jats:sup>\n                    and K\n                    <jats:sup>+<\/jats:sup>\n                    transport in the kidney. Consequently, CNIs cause hypertension, compromise renal K\n                    <jats:sup>+<\/jats:sup>\n                    excretion, and induce hyperkalemia.\n                  <\/jats:p>","DOI":"10.1111\/apha.14189","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T07:27:18Z","timestamp":1718090838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of calcineurin in regulating renal potassium (K\n                    <sup>+<\/sup>\n                    ) excretion: Mechanisms of calcineurin inhibitor\u2010induced hyperkalemia"],"prefix":"10.1111","volume":"240","author":[{"given":"Xin\u2010Peng","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Physiology Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Biao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology Xuzhou Medical University  Xuzhou China"},{"name":"Department of Pharmacology New York Medical College  Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-9554","authenticated-orcid":false,"given":"Wen\u2010Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology New York Medical College  Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-2684","authenticated-orcid":false,"given":"Dao\u2010Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology New York Medical College  Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91970-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92440-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91014-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/337476a0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/341758a0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/341755a0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2019.08.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07821109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163241"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-023-05335-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.5.F817"},{"key":"e_1_2_10_13_1","first-page":"F228","article-title":"Passive potassium transport in the proximal convoluted tubule","volume":"248","author":"Kaufman JS","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00603513"},{"key":"e_1_2_10_15_1","first-page":"F680","article-title":"Dependence of ion fluxes on fluid transport by rat proximal tubule","volume":"250","author":"Bomsztyk K","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_10_16_1","first-page":"F860","article-title":"A mathematical model of the rat proximal tubule","volume":"250","author":"Weinstein AM","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.196"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.166"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.371"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.009"},{"key":"e_1_2_10_21_1","first-page":"F745","article-title":"Control of NaCl transport in the thick ascending limb","volume":"246","author":"Hebert SC","year":"1984","journal-title":"Am J Physiol"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537500"},{"key":"e_1_2_10_23_1","first-page":"866","article-title":"The electroneutral Na+:(K+):Cl\u2212 cotransporters belong to the same family of proteins","volume":"4","author":"Gamba G","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32499-7"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115962"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200509360"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00238.2001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00687.2014"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00390.2013"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77357-1"},{"issue":"6","key":"e_1_2_10_31_1","first-page":"F1132","article-title":"ROMK inwardly rectifying ATP\u2010sensitive K+ channel. II. Cloning and distribution of alternative forms","volume":"268","author":"Boim MA","year":"1995","journal-title":"Am J Phys"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12110"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/362031a0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.413"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00051.2003"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.54.030192.000501"},{"key":"e_1_2_10_37_1","first-page":"F244","article-title":"A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop","volume":"258","author":"Wang W","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-152"},{"key":"e_1_2_10_39_1","first-page":"F970","article-title":"In situ studies of distal convoluted tubules in rat. II. K secretion","volume":"252","author":"Schnermann J","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00592.2010"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.2.F252"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014996"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21389"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2018"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118311"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071854"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00057.2007"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.5.F786"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00328.2015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40145"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.09.011"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.4.1483"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00636-4"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12091185"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070728"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00575.2016"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2497"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.165987"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000657"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800908"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0696-183"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.000679"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.077230"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.029223"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00176.2018"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01560-09"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.07.086"},{"key":"e_1_2_10_68_1","first-page":"F546","article-title":"Thiazide\u2010sensitive sodium chloride cotransport in early distal tubule","volume":"253","author":"Ellison DH","year":"1987","journal-title":"Am J Physiol"},{"issue":"6","key":"e_1_2_10_69_1","first-page":"422","article-title":"Mechanisms of sodium, potassium and chloride transport by the renal distal tubule","volume":"13","author":"Ellison DH","year":"1987","journal-title":"Miner Electrolyte Metab"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.24.14552"},{"issue":"6","key":"e_1_2_10_71_1","first-page":"F900","article-title":"Expression of the thiazide\u2010sensitive Na\u2010Cl cotransporter in rat and human kidney","volume":"269","author":"Obermuller N","year":"1995","journal-title":"Am J Phys"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00247.2012"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160312"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00159.2009"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V7102244"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001634"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.009"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121295"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1877"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208108200"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq525"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200947109"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111879"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016090948"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05718-0"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304592110"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062844"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10814"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2218"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-24"},{"key":"e_1_2_10_91_1","first-page":"F904","article-title":"Mutual dependence of sodium and chloride absorption by renal distal tubule","volume":"247","author":"Velazquez H","year":"1984","journal-title":"Am J Physiol"},{"key":"e_1_2_10_92_1","first-page":"F961","article-title":"The molecular basis of inherited hypokalemic alkalosis: Bartter's and Gitelman's syndromes","volume":"271","author":"Simon DB","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2030212"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.006"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.10.023"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272504"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00015.2014"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07389"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00067.2003"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90528.2008"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202112902"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00339.2013"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15933"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015040466"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.09.001"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.06.030"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020101406"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158498"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80304"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126910"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235360"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817281116"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016090935"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000127200"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02202-5"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00269.2006"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92331"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012961"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411705111"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.478453"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00288.2007"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0359f.x"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306596200"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00587.x"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00059.2018"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101400108"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00412.2018"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00112.2016"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00284.2020"},{"issue":"324","key":"e_1_2_10_130_1","article-title":"Chloride sensing by WNK1 involves inhibition of autophosphosphorylation","volume":"7","author":"piala AT","year":"2014","journal-title":"Forensic Sci"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503437112"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13948"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00528.2007"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.317"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157027"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519670"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.14189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T02:47:43Z","timestamp":1737514063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.14189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":135,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/apha.14189"],"URL":"https:\/\/doi.org\/10.1111\/apha.14189","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"assertion":[{"value":"2024-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14189"}}