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The landmark feature of OSA is chronic intermittent hypoxia (CIH), accounting for multiple organ damage, including heart disease. CIH profoundly alters both visceral white adipose tissue (WAT) and heart structure and function, but little is known regarding inter\u2010organ interaction in the context of CIH. We recently showed that visceral WAT senescence drives myocardial alterations in aged mice without CIH. Here, we aimed at investigating whether CIH induces a premature visceral WAT senescent phenotype, triggering subsequent cardiac remodeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a first experiment, 10\u2010week\u2010old C57bl6J male mice (<jats:italic>n<\/jats:italic>\u2009=\u200910\/group) were exposed to 14\u2009days of CIH (8\u2009h daily, 5%\u201321% cyclic inspired oxygen fraction, 60\u2009s per cycle). In a second series, mice were submitted to either epididymal WAT surgical lipectomy or sham surgery before CIH exposure. Finally, we used p53 deficient mice or Wild\u2010type (WT) littermates, also exposed to the same CIH protocol. Epididymal WAT was assessed for fibrosis, DNA damages, oxidative stress, markers of senescence (p16, p21, and p53), and inflammation by RT\u2010qPCR and histology, and myocardium was assessed for fibrosis and cardiomyocyte hypertrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CIH\u2010induced epididymal WAT remodeling characterized by increased fibrosis, oxidative stress, DNA damage response, inflammation, and increased expression of senescent markers. CIH\u2010induced epididymal WAT remodeling was associated with subtle and early myocardial interstitial fibrosis. Both epididymal WAT surgical lipectomy and p53 deletion prevented CIH\u2010induced myocardial fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Short\u2010term exposure to CIH induces epididymal WAT senescent remodeling and cardiac interstitial fibrosis, the latter being prevented by lipectomy. This finding strongly suggests visceral WAT senescence as a new target to mitigate OSA\u2010related cardiac disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apha.14231","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T13:22:42Z","timestamp":1726147362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chronic intermittent hypoxia triggers cardiac fibrosis: Role of epididymal white adipose tissue senescent remodeling?"],"prefix":"10.1111","volume":"240","author":[{"given":"Suzain","family":"Naushad","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, INSERM U955  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gaucher","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, INSERM U1300, CHU Grenoble Alpes, HP2  Grenoble 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