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Thus, lack of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    can lead to osteoporosis, with incidence rising both in absolute and age\u2010specific terms, while Mg\n                    <jats:sup>2+<\/jats:sup>\n                    deficiency is associated with type II diabetes. Prevention via vitamin D or estrogen is controversial, and the bioavailability of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    from supplements is significantly lower than that from milk products. Problems are likely to increase as populations age and the number of people on vegan diets surges. Developing new therapeutic strategies requires a better understanding of the molecular mechanisms involved in absorption by intestinal epithelia. The vitamin\u2010D dependent, active pathway for the uptake of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    from the upper small intestine involving TRPV6 is highly efficient but only accounts for about 20% of total uptake. Instead, most Ca\n                    <jats:sup>2+<\/jats:sup>\n                    uptake is thought to occur via passive paracellular diffusion across the ileum, although sufficiently high luminal concentrations are difficult to achieve.. Interestingly, colon and caecum also have a considerable capacity for the active absorption of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , the molecular mechanisms of which are unclear. Intriguingly, stimulating fermentation by prebiotics enhances colonic absorption, which can rise from ~10% to ~30% of the total. Notably, fermentation releases protons, which inhibits channels highly selective for Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    (TRPV6 and TRPM6\/TRPM7). Conversely, the non\u2010selective cation channel TRPV3 is stimulated by both intracellular acidification and by numerous herbal compounds. Spicy, fiber\u2010rich food, as traditionally consumed in many cultures, might enhance the uptake of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    via this pathway.\n                  <\/jats:p>","DOI":"10.1111\/apha.14262","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T05:36:08Z","timestamp":1736746568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prebiotics as modulators of colonic calcium and magnesium uptake"],"prefix":"10.1111","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-9237","authenticated-orcid":false,"given":"Friederike","family":"Stumpff","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine Health and Medical University Potsdam  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-1980","authenticated-orcid":false,"given":"David","family":"Manneck","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Health and Medical University Potsdam  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071986"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5083022"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.519"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61647-5"},{"key":"e_1_2_13_6_1","first-page":"18","article-title":"Issues in nutrition: dietary supplements","volume":"452","author":"Thompson ME","year":"2017","journal-title":"FP 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