{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:56:34Z","timestamp":1790283394486,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Pancreatic \u03b2\u2010cells are susceptible to inflammation, leading to decreased insulin production\/secretion and cell death. Previously, we have identified a novel triceps\u2010derived myokine, DECORIN, which plays a pivotal role in skeletal muscle\u2010to\u2010pancreas interorgan communication. However, whether DECORIN can directly impact \u03b2\u2010cell function and susceptibility to inflammation remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The effect of DECORIN was assessed in sorted human and rat \u03b2\u2010cell and human islets from healthy and type 2 diabetes (T2D) donors. We assessed glucose\u2010stimulated insulin secretion (GSIS) and cytokine\u2010mediated cell death. We then challenged sorted \u03b2\u2010cells and human islets with inflammatory cytokines commonly associated with diabetes, such as tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) alone or in combination with interleukin1\u2010\u03b2 (IL1\u2010\u03b2) and interferon\u2010\u03b3 (cytomix).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DECORIN enhanced cell spreading and the localization of phosphorylated FAK at adhesions, promoting GSIS under basal conditions. It also increased insulin granule docking adhesion length and countered the inhibitory effects of TNF\u2010\u03b1 on adhesion and actin remodeling at the \u03b2\u2010cell surface, resulting in preserved GSIS. DECORIN protected from cell death in sorted \u03b2\u2010cells and islets challenged with TNF\u2010\u03b1 alone or TNF\u2010\u03b1\u2009+\u2009cytomix. Interestingly, DECORIN increased both insulin content and secretion in human islets from T2D individuals. Additionally, DECORIN treatment reversed the impaired gene expression caused by T2D and enhanced the expression of genes essential for islet function and metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, we have shown that DECORIN had a beneficial effect on human islets, protecting them from inflammation\u2010induced cell death. In T2D islets, DECORIN restores islet function and reverses the expression of T2D\u2010associated genes. Based on our data, we propose that DECORIN is a promising therapeutic target for diabetes\u2010associated inflammation and diabetes itself.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.14267","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T03:00:23Z","timestamp":1737601223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>DECORIN<\/scp>\n                    , a triceps\u2010derived myokine, protects sorted \u03b2\u2010cells and human islets against chronic inflammation associated with type 2 diabetes"],"prefix":"10.1111","volume":"241","author":[{"given":"Allan","family":"Langlois","sequence":"first","affiliation":[{"name":"UR Diab\u00e8te et Th\u00e9rapeutiques, Centre europ\u00e9en d'\u00e9tude du Diab\u00e8te Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Cherfan","sequence":"additional","affiliation":[{"name":"UR Diab\u00e8te et Th\u00e9rapeutiques, Centre europ\u00e9en d'\u00e9tude du Diab\u00e8te Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Meugnier","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Inserm U1060, INRAE UMR1397, Univ\u2010Lyon Universit\u00e9 Claude Bernard Lyon\u20101  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Rida","sequence":"additional","affiliation":[{"name":"ILONOV, Boulevard Ren\u00e9 Leriche  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Arous","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, Centre M\u00e9dical Universitaire University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Peronet","sequence":"additional","affiliation":[{"name":"UR Diab\u00e8te et Th\u00e9rapeutiques, Centre europ\u00e9en d'\u00e9tude du Diab\u00e8te Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harzo","family":"Hamdard","sequence":"additional","affiliation":[{"name":"UR Diab\u00e8te et Th\u00e9rapeutiques, Centre europ\u00e9en d'\u00e9tude du Diab\u00e8te Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bader","family":"Zarrouki","sequence":"additional","affiliation":[{"name":"Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals R&amp;D  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Wehrle\u2010Haller","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, Centre M\u00e9dical Universitaire University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Pinget","sequence":"additional","affiliation":[{"name":"UR Diab\u00e8te et Th\u00e9rapeutiques, Centre europ\u00e9en d'\u00e9tude du Diab\u00e8te Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"ILONOV, Boulevard Ren\u00e9 Leriche  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan M.","family":"Craige","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods, and Exercise Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-5105","authenticated-orcid":false,"given":"Karim","family":"Bouzakri","sequence":"additional","affiliation":[{"name":"UR Diab\u00e8te et Th\u00e9rapeutiques, Centre europ\u00e9en d'\u00e9tude du Diab\u00e8te Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"ILONOV, Boulevard Ren\u00e9 Leriche  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9830-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2391"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77812"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00703"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/39335"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.12.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.048058"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3086167"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12166"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-9990"},{"issue":"5","key":"e_1_2_9_13_1","article-title":"Exercise training and insulin resistance: a current review","volume":"5","author":"Keshel TE","year":"2015","journal-title":"J Obes Weight Loss Ther"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.048074"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28117-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.07.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.11.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.49"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1178"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07797.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.20.7683"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.50.31767"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.023"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402976101"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.504530"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.09.009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/336244a0"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/346281a0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.029"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37501-x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.2939"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001868"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208329"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2800-1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.056"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0946"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.611111"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18702"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00268.2015"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116403"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(91)90025-8"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.09.024"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2016.919"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.178"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00080.2007"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01608"},{"issue":"2","key":"e_1_2_9_47_1","first-page":"209","article-title":"The proteoglycan decorin is synthesized and secreted by differentiated myotubes","volume":"55","author":"Brandan E","year":"1991","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.060"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.52082\/jssm.2022.616"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.12.017"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32545"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201600076"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.083"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0008"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0325"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23862-x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00149-3"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.143791"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040766"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.6.1319"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0855-1"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(90)90019-7"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.233"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02942"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.279885"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012957"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.14267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:58:55Z","timestamp":1765270735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.14267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/apha.14267"],"URL":"https:\/\/doi.org\/10.1111\/apha.14267","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14267"}}