{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:27Z","timestamp":1787237187767,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010249","name":"School of Medicine, Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n Left atrial (LA) strain is emerging as a valuable metric for evaluating cardiac function, particularly under pathological conditions such as pressure overload. This preclinical study investigates the predictive utility of LA strain on cardiac function in a murine model subjected to pressure overload, mimicking pathologies such as hypertension and aortic stenosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n High\u2010resolution ultrasound was performed in a cohort of mice (\n n<\/jats:italic>\n \u2009=\u200916) to evaluate left atrial and left ventricular function at baseline and 2 and 4\u2009weeks after transverse aortic constriction (TAC). Acute adaptations in cardiac function were assessed in a subgroup of mice (\n n<\/jats:italic>\n \u2009=\u200910) with 3\u2009days post\u2010TAC imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We report an increase in LA max volume from 11.0\u2009\u00b1\u20094.3\u2009\u03bcL at baseline to 26.7\u2009\u00b1\u200916.7\u2009\u03bcL at 4\u2009weeks (\n p<\/jats:italic>\n \u2009=\u20090.002) and a decrease in LA reservoir strain from 20.8\u2009\u00b1\u20095.4% at baseline to 10.2\u2009\u00b1\u20096.9% at 4\u2009weeks (\n p<\/jats:italic>\n \u2009=\u20090.001). In the acute phase, LA strain dysfunction was present at 3\u2009days (\n p<\/jats:italic>\n \u2009<\u20090.001), prior to alterations in LA volume (\n p<\/jats:italic>\n \u2009=\u20090.856) or left ventricular (LV) ejection fraction (\n p<\/jats:italic>\n \u2009=\u20090.120). LA reservoir strain correlated with key indicators of cardiac performance including left ventricular (LV) ejection fraction (\n r<\/jats:italic>\n \u2009=\u20090.541,\n p<\/jats:italic>\n \u2009<\u20090.001), longitudinal strain (\n r<\/jats:italic>\n \u2009=\u2009\u22120.637,\n p<\/jats:italic>\n \u2009<\u20090.001), and strain rate (\n r<\/jats:italic>\n \u2009=\u20090.378,\n p<\/jats:italic>\n \u2009=\u20090.007). Furthermore, markers of atrial structure and function including LA max volume (AUC\u2009=\u20090.813,\n p\u2009=<\/jats:italic>\n \u20090.003), ejection fraction (AUC\u2009=\u20090.853,\n p<\/jats:italic>\n \u2009=\u20090.001), and strain (AUC\u2009=\u20090.884,\n p<\/jats:italic>\n \u2009<\u20090.001) all predicted LV dysfunction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n LA strain and function assessments provide a reliable, non\u2010invasive method for the early detection and prediction of cardiac dysfunction in a model of pressure overload.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apha.14277","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:55:41Z","timestamp":1737024941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Left atrial reservoir strain as a predictor of cardiac dysfunction in a murine model of pressure overload"],"prefix":"10.1111","volume":"241","author":[{"given":"John P.","family":"Salvas","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana USA"},{"name":"Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4611-042X","authenticated-orcid":false,"given":"Thomas","family":"Moore\u2010Morris","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, University of Montpellier, CNRS, INSERM Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Goergen","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-3916","authenticated-orcid":false,"given":"Pierre","family":"Sicard","sequence":"additional","affiliation":[{"name":"PhyMedExp, IPAM\/Biocampus, University of Montpellier, INSERM, CNRS. Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.059"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01038-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab221"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-023-02968-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.09.021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2017.06.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072651"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.06.08"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.935103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae138"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.123.015735"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322516"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00038.2023"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048121"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.35.1.39"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.4.427"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002763"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.10.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125541"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16350"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.01.016"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jead287"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae072"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1079632"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14258"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.01.053"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300134"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.10.011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-8-14"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa415"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003754"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00133.2021"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3791\/57397"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74783"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00339.2017"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/APHA.13741"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.14277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:59:33Z","timestamp":1765270773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.14277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/apha.14277"],"URL":"https:\/\/doi.org\/10.1111\/apha.14277","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14277"}}