{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:36Z","timestamp":1787013876177,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001509","name":"Royal Society Te Ap\u0101rangi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009193","name":"Marsden Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Improper gastric emptying is implicated in several gastrointestinal disorders and may result from disrupted electromechanical coupling of the gastroduodenal junction (GDJ). Rhythmic \u201cslow waves\u201d and myogenic \u201cspikes\u201d are bioelectrical mechanisms that, alongside neural and hormonal co\u2010factors, control GDJ motility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To characterize the electromechanical effects of prokinetic (erythromycin) infusion and truncal vagotomy on pre\u2010clinical in\u00a0vivo porcine models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following ethical approval, the GDJ was exposed in anesthetized crossbreed weaner pigs (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200910), and custom high\u2010resolution electrodes were applied to the serosal surface. An EndoFLIP catheter (Medtronic, USA) was inserted orally and positioned across the pylorus to measure luminal diameter. In all subjects, control periods preceded intravenous infusion of erythromycin. In five of those subjects, truncal vagotomy was performed approximately an hour post\u2010infusion, before recording was resumed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to control recordings, erythromycin increased contractile amplitude ([2.9\u2009\u00b1\u20091.1] mm vs. [2.2\u2009\u00b1\u20090.9] mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and was associated with more consistent gastric slow\u2010wave rhythms and increased amplitude of slow waves and spikes. Surgical vagotomy immediately decreased contractile amplitude ([2.90\u2009\u00b1\u20091.1] mm vs. [1.2\u2009\u00b1\u20090.6] mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) and was associated with reduced slow\u2010wave amplitude, increased gastric and duodenal slow\u2010wave frequencies, and decreased spike patch coverage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, prokinetics and vagotomy produced opposing effects on GDJ electromechanical coupling and could inform diagnostic and interventional practices for patients with pathophysiological complications of this region.<\/jats:p>\n                  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