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Since pregnancy necessitates significant changes in both perfusion and metabolism for supporting fetal growth, surprising is that AMPK has received scant attention during pregnancy, perhaps due to the complexity of its actions and multiple maternal, placental, and fetal targets. Here we review human as well as experimental animal studies documenting AMPK activation's broad\u2010ranging maternal effects. Emphasized are those affecting vascular control and blood flow to the uteroplacental circulation under conditions of chronic hypoxia. Time and dosage\u2010dependent effects on the placenta and the fetus are also reviewed, revealing that AMPK activation affects all three\u2014maternal, placental, and fetal\u2014pregnancy compartments. We point to the need for an integrated study of AMPK's effects in each compartment during normal as well as fetal growth\u2010restricted (FGR) pregnancies. Since there are currently no therapies for FGR apart from early delivery, whereas there are drugs or nutritional substances activating AMPK approved for human use, such agents may represent new treatments. However, understanding their molecular mechanisms and specific actions in pregnancy compartments is required before conducting such trials.<\/jats:p>","DOI":"10.1111\/apha.70093","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:00:01Z","timestamp":1755594001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>AMPK<\/scp>: Accumulating Evidence in Support of its role in Dual Regulation of Vascular Function and Metabolism During Human Pregnancy"],"prefix":"10.1111","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-0025","authenticated-orcid":false,"given":"Lorna G.","family":"Moore","sequence":"first","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology University of Colorado Denver School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Wesolowski","sequence":"additional","affiliation":[{"name":"Section of Neonatology, Department of Pediatrics University of Colorado Denver School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n A.","family":"Lorca","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology University of Colorado Denver School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen G.","family":"Julian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Colorado Denver School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-31311-7_22"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108381"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.194274"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.593005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15863"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac223"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14592"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1957.02060040668009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.87.6.1003"},{"key":"e_1_2_10_11_1","first-page":"83","article-title":"Hypoxic Pregnancy in Sheep Alters Placental Mitochondrial Function, Structure and Energy Metabolism","volume":"29","author":"Tong W.","year":"2022","journal-title":"Reproductive Sciences"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1745181"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.t01-1-02163.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.04.004"},{"key":"e_1_2_10_15_1","first-page":"181","volume-title":"Handbook of Physiology","author":"Meschia G.","year":"2014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.1.7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00164.2008"},{"issue":"3","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1152\/jappl.1982.52.3.690","article-title":"Maternal Hyperventilation Helps Preserve Arterial Oxygenation During High\u2010Altitude Pregnancy","volume":"52","author":"Moore L. 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