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Cold\u2010evoked responses are severely blunted in\n                      <jats:italic>Trpa1<\/jats:italic>\n                      KO mice. In contrast, TRPM8 deletion or pharmacological TRPM8 blockade had little impact on VG cold sensitivity. In\n                      <jats:italic>Trpm8<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>eYFP<\/jats:italic>\n                      <\/jats:sup>\n                      reporter mice, VG TRPM8 expression was restricted to the rostral jugular ganglion. In\u00a0vivo labeling of airway\u2010innervating VG neurons demonstrated their enhanced cold sensitivity and higher TRPA1 expression compared to neurons innervating the stomach wall. In contrast, the majority of CS TG neurons co\u2010express TRPM8 markers, and their cold sensitivity is reduced after TRPM8 deletion or blockade. However, pharmacological or genetic ablation of TRPA1 confirmed its contribution to high\u2010threshold cold sensitivity in TG, suggestive of a role in noxious cold sensing. In both ganglia, a fraction of CS neurons responded to cooling by a mechanism independent of TRPA1 or TRPM8. Blocking potassium channels enhanced cold sensitivity independently of the specific transducer mechanism, suggestive of a common excitability brake mechanism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study highlights the differential contribution of TRPM8 and TRPA1 channels to cold sensitivity in somatic and visceral ganglia, establishing a critical role of TRPA1 channels in visceral cold transduction. Finally, cold sensitivity seems fine\u2010tuned to the specific physiological needs of different organs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70111","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:07:55Z","timestamp":1759399675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs"],"prefix":"10.1111","volume":"241","author":[{"given":"Katharina","family":"Gers\u2010Barlag","sequence":"first","affiliation":[{"name":"Instituto de Neurociencias de Alicante Universidad Miguel Hern\u00e1ndez\u2010CSIC  San Juan de Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana G\u00f3mez","family":"del Campo","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Alicante 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