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As the KP is stress\u2010responsive, this study examines how peripheral KP metabolites change with core temperature increases induced by two different modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized cross\u2010over study, 11 young healthy males were subjected to (a) exogenous heating via hot water immersion (44\u00b0C, EXO), and (b) exertional heating via exercise (EXE), until rectal temperature (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>rec<\/jats:sub>\n                      ) reached 39\u00b0C, followed by a recovery phase. Blood samples were collected at baseline and at every 0.5\u00b0C\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>rec<\/jats:sub>\n                      increment during both the heating and recovery phases. Plasma levels of KP metabolites, stress, and metabolic markers were measured. Correlation analyses between kynurenine pathway metabolites and stress markers were computed over the course of the trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EXE and EXO trials induced the KP, but to different extents. Most plasma KP metabolite concentrations (kynurenic acid, picolinic acid, 3\u2010hydrokynurenine, quinolinic acid) increased. Stress markers were elevated in both trials. Changes in KP metabolites, stress, and metabolic markers were not persistent, and returned to baseline following recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An elevation in body temperature by heat exposure or exercise increases peripheral concentration of several KP metabolites that return to baseline upon trial cessation, suggesting that KP enzymes are adaptable to physiological stressors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70123","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:58:48Z","timestamp":1762883928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Heat Exposure on Kynurenine Pathway Metabolism\u2014Comparison Between Exertional and Exogenous Heating of the Human 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