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Clinically, DM1 is characterized by progressive muscle weakness and atrophy, resulting in reduced physical capacity and quality of life. Recent evidence implicates mitochondrial dysfunction in DM1 pathophysiology. While aerobic exercise has been shown to improve skeletal muscle and mitochondrial health in individuals with DM1, the benefits of strength training remain unexplored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the effects of a 12\u2010week strength training program on mitochondrial respiration, reactive oxygen species (ROS) production and muscle integrity in women with DM1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Vastus lateralis muscle biopsies were collected pre\u2010 and post\u2010training in participants with DM1 and once in unaffected\/untrained individuals. Mitochondrial respiration and hydrogen peroxide emission (marker of ROS production) were assessed in permeabilized myofibers, while OXPHOS protein contents were quantified by immunoblotting and immunofluorescence. Markers of myofiber denervation (NCAM+) and integrity (centrally located myonuclei, damaged laminin, nuclear clumps) were assessed on histological sections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, DM1 participants exhibited lower mitochondrial respiration compared to unaffected individuals. Strength training significantly improved mitochondrial respiration and content in DM1 participants. At baseline, absolute ROS production was lower, while ROS production normalized to oxygen consumption (free radical leak) was higher, in DM1. Histological signs of denervation and altered muscle integrity were observed. Strength training partially normalized mitochondrial free radical leak and restored some markers of myofiber integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, our results indicate that strength training enhances mitochondrial health and improves myofiber integrity in women with DM1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70135","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T17:20:55Z","timestamp":1763313655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A 12\u2010Week Strength Training Improves Mitochondrial Respiration,\n                    <scp>\n                      H\n                      <sub>2<\/sub>\n                      O\n                      <sub>2<\/sub>\n                    <\/scp>\n                    Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1"],"prefix":"10.1111","volume":"241","author":[{"given":"Vincent","family":"Marcangeli","sequence":"first","affiliation":[{"name":"Department of Physical Activity Sciences Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montreal Quebec Canada"},{"name":"Research Group for Adapted Physical Activity Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montr\u00e9al Quebec Canada"},{"name":"Department of Biological Sciences Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Girard\u2010C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences, Faculty of Medicine Universit\u00e9 Laval  Quebec City Quebec Canada"},{"name":"CHU de Qu\u00e9bec\u2014Universit\u00e9 Laval Research Center  Quebec City Quebec Canada"},{"name":"Neuromuscular Diseases 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