{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:31:00Z","timestamp":1785569460124,"version":"3.56.0"},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ependymal cell\u2010derived perilesional glial borders may play a beneficial role in neural regeneration after spinal cord injury (SCI). Yes\u2010associated protein (YAP), a key transcriptional cofactor, is involved in the control of body organ size by regulating cell differentiation, proliferation, growth, and apoptosis; however, it remains unclear whether the roles and underlying mechanisms of YAP signaling regulate the ependymal cell\u2010derived perilesional glial borders after SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We established a dorsal cord incision injury mouse model. The YAP\n                      <jats:sup>f\/f<\/jats:sup>\n                      ; FoxJ1\u2010CreERT2 (YAP\n                      <jats:sup>FoxJ1\u2010ERT2<\/jats:sup>\n                      \u2010CKO) mice and YAP\n                      <jats:sup>f\/f<\/jats:sup>\n                      ; FoxJ1\u2010CreERT2; Rosa26\n                      <jats:sup>tdTomato<\/jats:sup>\n                      mice were generated to examine the roles of ependymal YAP signaling in SCI. The RNA\u2010seq, western blot, immunostaining, and cell\u2010fate tracing tools were used to investigate the underlying mechanisms of YAP signaling in the regulation of ependymal cell\u2010derived perilesional glial borders after SCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      YAP was activated in ependymal cells after SCI. Interestingly, YAP deletion in ependymal cells (YAP\n                      <jats:sup>FoxJ1\u2010ERT2<\/jats:sup>\n                      \u2010CKO mice) aggravated the neuronal loss and impaired the formation of perilesional glial borders and then inhibited the functional recovery after SCI. Furthermore, YAP deletion inhibited the proliferation and differentiation of ependymal cells to astrocytes and oligodendrocytes and reduced the secretion of neurotrophic factors after SCI. Mechanically, RNA\u2010seq revealed that the expression of Colorectal Neoplasia Differentially Expressed (CRNDE) was downregulated in YAP\n                      <jats:sup>FoxJ1\u2010ERT2<\/jats:sup>\n                      \u2010CKO mice. Furthermore, we found downregulation of P300 and \u03b2\u2010catenin and upregulation of GSK\u20103\u03b2 in YAP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ependymal cells after SCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ependymal YAP signaling promotes the formation of ependymal cell\u2010derived perilesional glial borders in mice through the P300\u2010CRNDE\u2010Wnt\/\u03b2\u2010catenin pathway after SCI, which provides a novel target for SCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70147","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T08:47:25Z","timestamp":1766825245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ependymal Yes\u2010Associated Protein Promotes the 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