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Co\u2010immunoprecipitation and PLA assays indicated that p11 interacts with Munc13\u20101, a presynaptic active zone (AZ) protein for vesicle priming, presumably at excitatory inputs in the hypoglossal nucleus. Interference with p11 resulted in Munc13\u20101 downregulation, reduction in AZ length, and increased vesicle accumulation at excitatory boutons on HMNs, without affecting the number of docked vesicles at the AZ. p11 knockdown robustly reduced the synaptic strength of excitatory neurotransmission incoming to HMNs by affecting both the synchronous and asynchronous phases of neurotransmitter release. The decrease in synaptic strength was concurrent with a reduction in the size of the \u201cfunctional\u201d pool of readily releasable (RRP) vesicles and with the slowing down of the vesicle recruitment rate to replenish RRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>p11 is proposed as a relevant mediator in the neurotransmitter release by regulating vesicle dynamics at central excitatory synapses. Here, p11 is highlighted as a multifaceted factor involved in neurotransmission and synaptic plasticity and, therefore, central for neural information processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70158","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:53:13Z","timestamp":1768207993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Calcium\u2010Binding Protein\n                    <scp>S100A10<\/scp>\n                    (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses"],"prefix":"10.1111","volume":"242","author":[{"given":"Esther","family":"Vilches\u2010Herrando","sequence":"first","affiliation":[{"name":"GRUpo de NEuroDEgeneraci\u00f3n y NeurorREparaci\u00f3n (GRUNEDERE), \u00c1rea de Fisiolog\u00eda, Facultad de Medicina Universidad de C\u00e1diz  C\u00e1diz Spain"},{"name":"Instituto 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