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This study investigated acute effects of ketosis on metabolic economy, mitochondrial function, and contractile parameters in skeletal muscle of young and older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twelve young (20\u201325\u2009years) and twelve older (65\u201385\u2009years) healthy men, matched by age\u2010adjusted V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      max, participated in a randomized, crossover, double\u2010blind intervention with ingestion of ketone monoester or placebo on separate study days. On both days, a low\u2010dose, continuous glucose infusion blocked endogenous ketone production. Metabolic economy, oxidative capacity, muscle performance, intramuscular pH, and relative decline in peak power were assessed in the tibialis anterior through phosphorous MR spectroscopy (\n                      <jats:sup>31<\/jats:sup>\n                      P\u2010MRS) and dynamometer recordings. Mitochondrial function of the quadriceps femoris muscle was assessed by high\u2010resolution respirometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ketosis had no effect on metabolic economy in either young or older participants. The older group showed lower metabolic economy compared to the young group. In older participants, ketones increased ATP production and time\u2010torque derived work capacity. Oxidative capacity was similar between groups and remained unaffected by ketones. In the older group, ketones improved peak power and increased both muscle relative decline in peak power\u00a0and contraction\u2010induced pH decline. Complex I\u2009+\u2009II respiration was lower in older compared to young participants, with no effect of ketones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ketosis enhanced skeletal muscle work capacity and ATP production in older but not young adults, suggesting an age\u2010specific effect of ketone bodies on muscle function that operates independently of changes in metabolic economy and mitochondrial function. These findings support ketosis as a promising ergogenic therapy for older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The study was pre\u2010registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      (NCT05732909)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70161","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:00:17Z","timestamp":1770350417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ketone Monoester Increases Skeletal Muscle Power and Energy Turnover in Older but Not Young Men Without Affecting Metabolic Economy: A Controlled, Double Blind, Cross\u2010Over Trial"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-1677","authenticated-orcid":false,"given":"Ole Emil","family":"Andersen","sequence":"first","affiliation":[{"name":"Section of Sport Science, Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus  Aarhus Denmark"},{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-1453","authenticated-orcid":false,"given":"Ryan Godsk","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Faculty of Medicine Aalborg University  Aalborg 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