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Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium\u2010derived hyperpolarization\u2010mediated relaxation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Radial arteries isolated from the uterus of NT and PE pregnant patients were incubated with pravastatin (2\u2009mM\/6\u2009h), methyl\u2010\u03b2\u2010cyclodextrin (10\u2009mM\/1\u2009h) in\u00a0vitro, or vehicle. Vessel function was determined with pressure myography, while related morphology and protein\/mRNA expression were characterized using immunohistochemistry, electron microscopy, and qPCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Endothelium\u2010dependent, bradykinin\u2010induced NO\u2010mediated relaxation was impaired in radial arteries from PE compared to NT pregnancy, with a reduced intermediate\u2010 and large\u2010conductance Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \u2010activated K\n                      <jats:sup>+<\/jats:sup>\n                      \u2010channel contribution. Endothelial small\u2010conductance Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \u2010activated K\n                      <jats:sup>+<\/jats:sup>\n                      \u2010channel function and expression were increased in arteries from PE, compared to NT patients. Pravastatin restored NO and endothelium\u2010derived hyperpolarization\u2010mediated relaxation in arteries from PE women; potentially overcompensating overall endothelium\u2010dependent relaxation. Myoendothelial gap junction and endothelial caveolae density, and caveolin\u20101 and endothelial\u2010NOS expression were decreased in arteries from PE relative to NT pregnancies and increased following pravastatin incubation. Caveolae density in NT patient arteries was reduced by methyl\u2010\u03b2\u2010cyclodextrin, while endothelial caveolae were increased in vessels from PE patients. Pravastatin incubation restored endothelial function via improved NO and endothelium\u2010derived hyperpolarization\u2010type mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pravastatin restored endothelium\u2010dependent relaxation in uterine radial arteries from PE pregnancies. Data support the therapeutic potential for pravastatin in treating PE, with ongoing trials determining the validity of its use in the clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT01717586\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70186","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:00:23Z","timestamp":1773212423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pravastatin Corrects Endothelial Dysfunction in Ex\u00a0Vivo Uterine Radial Arteries in Preeclampsia"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-566X","authenticated-orcid":false,"given":"Nathan M.","family":"Luque","sequence":"first","affiliation":[{"name":"Physiology, School of Biomedical Sciences University of New South Wales  Sydney New South Wales Australia"},{"name":"Medicine, Blacktown Clinical School and Research Centre Western Sydney University  Blacktown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6644-690X","authenticated-orcid":false,"given":"Leo","family":"Leader","sequence":"additional","affiliation":[{"name":"Women's Health and Royal Hospital for Women University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-6011","authenticated-orcid":false,"given":"Sandra 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