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Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin\u201010 (Kp10) has been shown to improve feto\u2010placental development in hypothyroid rats, this study aimed to evaluate the effects of maternal hypothyroidism, with and without kisspeptin\u201010 treatment, on maternal energy homeostasis and placental expression of mTOR and glucose metabolism mediators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Maternal hypothyroidism was induced by administration of propylthiouracil, and kisspeptin\u201010 treatment began on gestational day 8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Maternal hypothyroidism caused glucose intolerance, decreased insulin and HDL levels, reduced fetal and placental weights, and thinned the placental interhaemal barrier. It also increased INSR\u03b2 and AKT, while downregulating placental p\u2010mTOR\/mTOR and Glut1. Although kisspeptin\u201010 treatment did not improve maternal glucose homeostasis or prevent feto\u2010placental growth restriction, it attenuated maternal hypothyroidism\u2010induced placental Glut1 dysregulation, upregulated the IGF1\/IGF1R axis, and restored placental AKT\/mTOR expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that kisspeptin\u201010 treatment in hypothyroid pregnant rats improves placental mTOR signaling and glucose metabolism mediators, highlighting novel pathways through which kisspeptin may modulate placental physiology.<\/jats:p>\n                  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