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These responses offer a unique window into how individual neurons encode high\u2010level, multimodal representations\u2014the building blocks of episodic memory\u2014that differ from the more distributed, often hierarchical representations supporting semantic memory in the neocortex. Episodic and semantic memory, the systems for storing past experiences and conceptual knowledge, have traditionally been regarded as distinct. However, converging evidence from neuroimaging, lesion studies, and electrophysiological recordings challenges this strict dichotomy. This review synthesizes findings from human single\u2010neuron recordings to re\u2010examine the traditional distinction between episodic and semantic memory. 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