{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:00:42Z","timestamp":1785121242513,"version":"3.55.0"},"reference-count":95,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17SA0031406"],"award-info":[{"award-number":["NNF17SA0031406"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. 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Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we profiled 754 microRNAs and 58\u2009191 gene transcripts (19\u2009919 protein\u2010coding) in up to 131 different human islet donor preparations (without diabetes) and assessed their association with donor traits. Additionally, the effect of the age\u2010associated key microRNAs on relative telomere length in human islet\u2010derived cells was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MicroRNA discovery analyses identified miR\u2010199a\u20105p and miR\u2010214\u20103p to be associated (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value \u2264\u20090.05) with all three traits (i.e., sex, age, and BMI); miR\u2010147b\u20103p with sex and age; miR\u2010378a\u20105p with sex and BMI; miR\u2010542\u20103p, miR\u201034a\u20103p, miR\u201034a\u20105p, miR\u2010497\u20105p and miR\u201099a\u20105p with age and BMI. After adjusting for covariates, 612 protein\u2010coding gene transcripts associated with sex (excluding those from sex\u2010chromosomes), 902 with age, and 250 with BMI. MicroRNA\u2010199a\u20105p and miR\u2010214\u20103p levels negatively correlated with mRNAs critical in islet function, metabolic regulation, and senescence. In\u00a0vitro validation studies verified that inhibition of two common microRNAs (miR\u2010199a\u20105p\/\u2010214\u20103p) slowed down telomere length shortening in human islet\u2010derived cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our analyses identify human islet microRNAs associated with donor traits and provide evidence that these microRNAs can potentially modulate cellular aging phenotype (reflected by relative telomere length) in human islet\u2010derived cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70277","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:51:07Z","timestamp":1785073867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Islet\n                    <scp>miR<\/scp>\n                    \u2010199a\u20105p and\n                    <scp>miR<\/scp>\n                    \u2010214\u20103p Associate With Donor Age,\n                    <scp>BMI<\/scp>\n                    , and Sex and Mediate Cellular Aging in Islet\u2010Derived Cells"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-6834","authenticated-orcid":false,"given":"Wilson K. 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