{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:21:46Z","timestamp":1787664106341,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF22OC0080736"],"award-info":[{"award-number":["NNF22OC0080736"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022854","name":"European Cystic Fibrosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Secretin was recently found to play a pivotal role in the renal adaptation to acute base excess. Here, secretin increases pendrin\u2010dependent HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      secretion from the beta\u2010intercalated cells in the cortical collecting ducts. Whether secretin and its receptor play a role during prolonged base\u2010loading remains unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Urine and blood acid\u2013base analyses were carried out in secretin receptor (SCTR) KO and WT mice at baseline and after 1 and up to 8\u2009days of base\u2010loading with NaHCO\n                      <jats:sub>3<\/jats:sub>\n                      \u2010enriched drinking water. Changes in pendrin protein abundance and function were assessed by immunoblotting and isolated tubule perfusion experiments. Plasma secretin levels and renal SCTR expression were assessed after 24\u2009h of acid\/base\u2010loading by radioimmunoassay and qPCR, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SCTR KO mice responded with diminished urine alkalization and a lesser reduction of urinary acid excretion when base\u2010loaded for 48\u2009h. Concordantly, SCTR KO mice presented with increased blood base retention compared with WTs. Base\u2010loaded SCTR WT and KO mice showed comparable total pendrin protein abundance. Despite this, pendrin function was markedly lower in SCTR KO mice. Base\u2010loaded mice had higher plasma secretin and renal SCTR levels compared with acid\u2010loaded mice. Higher arterial HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      associated with higher renal SCTR mRNA expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Loss of the SCTR diminishes renal base excretion capacity and exacerbates systemic base accumulation during prolonged base\u2010loading. Further, plasma secretin and renal SCTR mRNA levels are modulated by acid\u2013base intake. These findings further support a central role of secretin and its receptor in the regulation of both acute and prolonged base excess.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70286","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:52:03Z","timestamp":1785498723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impaired Renal Base Excretion in Secretin Receptor Knock\u2010Out Mice During Prolonged Base\u2010Loading"],"prefix":"10.1111","volume":"242","author":[{"given":"Tobias","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Frank","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 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