{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:21:50Z","timestamp":1787664110541,"version":"build-2736575974"},"reference-count":140,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1221257"],"award-info":[{"award-number":["1221257"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1211838"],"award-info":[{"award-number":["1211838"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["3220672"],"award-info":[{"award-number":["3220672"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21250795"],"award-info":[{"award-number":["21250795"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["Anillo de Tecnolog\u00eda ACT250073"],"award-info":[{"award-number":["Anillo de Tecnolog\u00eda ACT250073"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000292","name":"Cystic Fibrosis Trust","doi-asserted-by":"publisher","award":["DA004"],"award-info":[{"award-number":["DA004"]}],"id":[{"id":"10.13039\/501100000292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Maintenance of potassium (K\n                    <jats:sup>+<\/jats:sup>\n                    ) homeostasis across cell membranes is essential for life. While systemic K\n                    <jats:sup>+<\/jats:sup>\n                    balance is primarily regulated by the kidneys and intestines, ion channels, pumps, and transporters govern K\n                    <jats:sup>+<\/jats:sup>\n                    movement across epithelial barriers at the cellular level. Despite the prevalence of diseases caused by disrupted K\n                    <jats:sup>+<\/jats:sup>\n                    homeostasis, the role of K\n                    <jats:sup>+<\/jats:sup>\n                    channels in the lungs has received comparatively little attention. The airway epithelium expresses a diverse array of K\n                    <jats:sup>+<\/jats:sup>\n                    channels that regulate key functions such as transepithelial ion transport, ciliary beating, and mucus secretion. These processes are fundamental components of mucociliary clearance (MCC), the primary innate defense mechanism of the lungs. Dysfunction of MCC is central to muco\u2010obstructive diseases, including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and asthma. While K\n                    <jats:sup>+<\/jats:sup>\n                    channels were once considered therapeutic targets for enhancing anion secretion in CF, initial interest waned. However, it has been reinvigorated by recent findings showing that drugs targeting CFTR can also modulate airway epithelial K\n                    <jats:sup>+<\/jats:sup>\n                    channels and facilitate MCC. In this review, we compile current evidence on targeting K\n                    <jats:sup>+<\/jats:sup>\n                    channels to treat muco\u2010obstructive diseases. We discuss therapeutic opportunities offered by K\n                    <jats:sup>+<\/jats:sup>\n                    channel modulators, highlight emerging functions of these channels in the airways, and outline priorities for future research.\n                  <\/jats:p>","DOI":"10.1111\/apha.70287","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:27:05Z","timestamp":1785817625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potassium Channels of the Airway Epithelium"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-145X","authenticated-orcid":false,"given":"Sandra","family":"Villanueva","sequence":"first","affiliation":[{"name":"Centro de Estudios Cient\u00edficos (CECs)  Valdivia Chile"},{"name":"Facultad de Medicina Universidad San Sebasti\u00e1n  Valdivia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6887-5237","authenticated-orcid":false,"given":"Erwin","family":"Vera","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cient\u00edficos (CECs)  Valdivia Chile"},{"name":"Facultad de Medicina Universidad San Sebasti\u00e1n  Valdivia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e1bata","family":"Apablaza","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cient\u00edficos (CECs)  Valdivia Chile"},{"name":"Estudiante Programa de Doctorado en Enfermedades Cr\u00f3nicas, Facultad de Medicina Universidad San Sebasti\u00e1n  Valdivia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-2821","authenticated-orcid":false,"given":"Marcelo A.","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Universidad Austral de  Valdivia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-1909","authenticated-orcid":false,"given":"Carlos A.","family":"Flores","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cient\u00edficos (CECs)  Valdivia Chile"},{"name":"Facultad de Medicina Universidad San Sebasti\u00e1n  Valdivia Chile"},{"name":"NanoAIR Center (ACT250073)  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08580813"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-022-02718-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0781-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.04.005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000976"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116513"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP287415"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/pulp.1993.1022"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90525.2008"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215217"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118761429368288250401054301"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81724-9"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(74)90071-1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028241"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201804-238AW"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12085"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0451-9"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202309-1565OC"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan8546"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2024-0225OC"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.402"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2014.02.001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.43.3.383"},{"key":"e_1_2_12_25_1","first-page":"323","article-title":"Contribution Experimental Al'etude du Dlveloppement Prenatal du Poumon Chez le Lapin","volume":"32","author":"Jost A.","year":"1948","journal-title":"Archives D'anatomie Microscopique"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)40561-2"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-82-20105"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013754"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010659"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.803513"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.50.3.613"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.3.706"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.5.1542"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.6.L1213"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119802"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808021200"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123616"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5589"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116365"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8823"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.34.21542"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.3.C848"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-003-0621-3"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000057204.51420.DC"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-002-1009-5"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140076"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49767-6"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145259"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.205138"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00515.x"},{"key":"e_1_2_12_51_1","first-page":"S163","article-title":"Airway Hydration, Apical K+ Secretion, and the Large\u2010Conductance, Ca2+\u2212Activated and Voltage\u2010Dependent Potassium (BK) Channel","volume":"13","author":"Kis A.","year":"2016","journal-title":"Annals of the American Thoracic Society"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034038"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281952"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.185074"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP274200"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701786"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703081114"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2019149118"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.051102"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.181933"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000741200"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.483"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.23.3.4060"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105014200"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.047829"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.134387"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275178"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27465-3"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505860102"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.479360"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/35003200"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.047"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00102.2011"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167919"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.108459"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2019.104642"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00428"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139284"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05043-5"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00024.2023"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1813799"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2391-y"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22700"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2026.01.010"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14124335"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009005000028"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.237bz.x"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.2.C461"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgaf211"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.06.002"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00908.2025"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201905-0990OC"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI191824"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176328"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.51.030189.002125"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80624-4"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S23"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01869469"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.02.025"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.183541"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00511.2007"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.127498"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12184"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030323-042845"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011453"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.04.002"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00509-2020"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1279"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.70062"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0274"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11038-x"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03824-9"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010638"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.02.011"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01487-4"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2025.03.003"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1990.258.6.L334"},{"key":"e_1_2_12_119_1","first-page":"625","article-title":"Molecular Mechanism of Product Storage and Release in Mucin Secretion. II. The Role of Extracellular Ca++","volume":"24","author":"Verdugo P.","year":"1987","journal-title":"Biorheology"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0103OC"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00134.2021"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00559"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145259"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517666"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0068-2019"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03730-7"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-110098"},{"key":"e_1_2_12_128_1","first-page":"234","article-title":"The Effect of Bepridil on Respiratory and Cardiovascular Function: A Placebo\u2010Controlled Study","volume":"21","author":"Forche G.","year":"1983","journal-title":"International Journal of Clinical Pharmacology, Therapy, and Toxicology"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1992.tb00122.x"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5198(19)39892-0"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00816.x"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00181209"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.70270"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00477-9"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041505"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00058.2013"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-022-01056-9"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200072"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.70051"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010025\u201001677\u20106"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2024.39.S1.805"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apha.70287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:50:32Z","timestamp":1787662232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.70287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":140,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/apha.70287"],"URL":"https:\/\/doi.org\/10.1111\/apha.70287","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70287"}}