{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:01:27Z","timestamp":1790240487681,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The myogenic response contributes considerably to blood flow autoregulation. Intracellular pH (pH\n                      <jats:sub>i<\/jats:sub>\n                      ) has a substantial impact on small artery contractility. However, the role of putative pH\n                      <jats:sub>i<\/jats:sub>\n                      changes during myogenic constriction is unknown. Therefore, the hypothesis was tested that changes in pH\n                      <jats:sub>i<\/jats:sub>\n                      are associated with and contribute to the myogenic response in small arteries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rat small tail arteries were studied using isobaric myography and BCECF\u2010 as well as FURA\u20102\u2010fluorimetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that in response to a pressure increase, pH\n                      <jats:sub>i<\/jats:sub>\n                      decreased. It initially reached a peak and then recovered partly. The initial pH\n                      <jats:sub>i<\/jats:sub>\n                      peak is augmented in bicarbonate\u2010free solution, but was not affected by inhibitors of Na\n                      <jats:sup>+<\/jats:sup>\n                      \/H\n                      <jats:sup>+<\/jats:sup>\n                      exchange. The pH\n                      <jats:sub>i<\/jats:sub>\n                      recovery was not altered in bicarbonate\u2010free solution, but was reduced by inhibitors of Na\n                      <jats:sup>+<\/jats:sup>\n                      \/H\n                      <jats:sup>+<\/jats:sup>\n                      exchange. Proton fluxes were larger at 80\u2009mmHg than at 10\u2009mmHg. Bicarbonate\u2010free solution had no effect on proton fluxes at either 80\u2009mmHg or 10\u2009mmHg. Inhibitors of Na\n                      <jats:sup>+<\/jats:sup>\n                      \/H\n                      <jats:sup>+<\/jats:sup>\n                      exchange reduced proton fluxes only at 80\u2009mmHg. Pressure\u2010induced changes in intracellular calcium were not affected by either bicarbonate\u2010free solution or inhibitors of Na\n                      <jats:sup>+<\/jats:sup>\n                      \/H\n                      <jats:sup>+<\/jats:sup>\n                      exchange.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study showed that in rat small tail arteries a pressure increase is accompanied by a decrease in pH\n                      <jats:sub>i<\/jats:sub>\n                      that appears to facilitate the myogenic response. The results of this study suggest that the pressure\u2010induced immediate fall in pH\n                      <jats:sub>i<\/jats:sub>\n                      is caused by a release of protons from the contractile machinery, and that the subsequent pH\n                      <jats:sub>i<\/jats:sub>\n                      recovery is due to activation of Na\n                      <jats:sup>+<\/jats:sup>\n                      \/H\n                      <jats:sup>+<\/jats:sup>\n                      exchange.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70309","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:38:36Z","timestamp":1789619916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pressure\u2010Induced Changes in Intracellular p\n                    <scp>H<\/scp>\n                    Facilitate the Myogenic Response of Rat Small Tail Arteries"],"prefix":"10.1111","volume":"242","author":[{"given":"Ulrike","family":"Krien","sequence":"first","affiliation":[{"name":"Physiology, Institute of Theoretical Medicine, Faculty of Medicine University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-1461","authenticated-orcid":false,"given":"Rudolf","family":"Schubert","sequence":"additional","affiliation":[{"name":"Physiology, Institute of Theoretical Medicine, Faculty of Medicine University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.2.387"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0960313"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.2.973"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"67","article-title":"Arteriolar Myogenic Signalling Mechanisms: Implications for Local Vascular Function","volume":"34","author":"Hill M. 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