{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:04:35Z","timestamp":1790661875433,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Traumatic brain injury is one of the leading causes of death and disability worldwide, and its pathological and physiological mechanisms are complex. In recent years, the research perspective centered on neurovascular units has revealed the crucial role of microcirculation disorders after traumatic brain injury. This article reviews the pathological manifestations of microcirculation disorders after traumatic brain injury and their interaction mechanisms with damage to various components of neurovascular units (endothelial cells, pericytes, astrocytes), and a new hypothesis of \u201cThe Reservoir Gate Theory\u201d in brain tissue microcirculation is proposed.<\/jats:p>","DOI":"10.1111\/apha.70315","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:43:51Z","timestamp":1790660631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Reservoir Gate Theory: Microcirculatory Changes Involving Neurovascular Units After Traumatic Brain Injury"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-5966","authenticated-orcid":false,"given":"Dan","family":"Ye","sequence":"first","affiliation":[{"name":"Fuzong Clinical Medical College Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Lin","sequence":"additional","affiliation":[{"name":"Fuzong Clinical Medical College Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Chen","sequence":"additional","affiliation":[{"name":"Fuzong Clinical Medical College Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-7846","authenticated-orcid":false,"given":"Shousen","family":"Wang","sequence":"additional","affiliation":[{"name":"Fuzong Clinical Medical College Fujian Medical University  Fuzhou Fujian China"},{"name":"Department of Neurosurgery 900th Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"11","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic Brain Injury: Progress and Challenges in Prevention, Clinical Care, and Research","volume":"21","author":"Maas A. 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A Wide Talk on Animal Models and Future Perspective","volume":"21","author":"Kundu S.","year":"2023","journal-title":"Current Neuropharmacology"},{"issue":"9","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41593-021-00904-7","article-title":"Revisiting the Neurovascular Unit","volume":"24","author":"Schaeffer S.","year":"2021","journal-title":"Nature Neuroscience"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00334","article-title":"Neurovascular Unit Dysfunction and Neurodegenerative Disorders","volume":"14","author":"Yu X.","year":"2020","journal-title":"Frontiers in Neuroscience"},{"issue":"5","key":"e_1_2_6_6_1","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70409","article-title":"Impact of NA\u20101 on Pericyte\u2010Driven Vasoconstriction and Its Role in No\u2010Reflow During Cerebral Ischemia\u2010Reperfusion","volume":"31","author":"Yang X.","year":"2025","journal-title":"CNS Neuroscience & Therapeutics"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuint.2019.03.011","article-title":"Cerebrovascular inflammation: A critical trigger for neurovascular injury?","volume":"126","author":"Naveed M.","year":"2019","journal-title":"Neurochemistry International"},{"issue":"51","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000040951","article-title":"Pathological Roles of Mitochondrial Dysfunction in Endothelial Cells During the Cerebral No\u2010Reflow Phenomenon: A Review","volume":"103","author":"Luo X.","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2013.00080","article-title":"Pericytes: Brain\u2010Immune Interface Modulators","volume":"7","author":"Hurtado\u2010Alvarado G.","year":"2014","journal-title":"Frontiers in Integrative Neuroscience"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1166770","article-title":"Glial Cells: An Important Switch for the Vascular Function of the Central Nervous System","volume":"17","author":"Gao L.","year":"2023","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1518967","article-title":"Role of Aquaporins in Brain Water Transport and Edema","volume":"19","author":"Li Y.","year":"2025","journal-title":"Frontiers in Neuroscience"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apha.70315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:43:53Z","timestamp":1790660633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.70315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/apha.70315"],"URL":"https:\/\/doi.org\/10.1111\/apha.70315","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70315"}}