{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:38:40Z","timestamp":1792733920575,"version":"4.5.0"},"reference-count":183,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL142808"],"award-info":[{"award-number":["HL142808"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL146914"],"award-info":[{"award-number":["HL146914"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL167208"],"award-info":[{"award-number":["HL167208"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY034238"],"award-info":[{"award-number":["EY034238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The renin\u2010angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications. Ang II exerts its vascular actions primarily through the angiotensin II type 1 receptor (AT1R), activating canonical and non\u2010canonical signaling pathways that extend beyond classical G\u2010protein\u2010dependent signaling mechanisms. Here, we review the literature on tissue\u2010specific RAS, Ang II\u2010dependent and Ang II\u2010independent signaling mechanisms of vascular Ang II receptors, and their contribution to vasoconstriction, endothelial dysfunction, vascular remodeling, and arterial stiffness in hypertension. We highlight the roles of mechanosensitive AT1R signaling, dysregulation of vascular ion channels, enhanced reactive oxygen species production, immune and inflammatory signaling, and mineralocorticoid receptor activation as key drivers of hypertensive vascular pathology. In addition, we discuss tissue\u2010specific expression of RAS components and separation between RAS pathways underlying blood pressure elevation and vascular remodeling in hypertension. Collectively, emerging research on vascular Ang II receptor signaling reveals novel regulatory mechanisms and therapeutic opportunities beyond conventional RAS inhibition. Targeting downstream pathways that mediate oxidative stress, mechanotransduction, ion channel activity, and profibrotic signaling may offer improved strategies to prevent or reverse Ang II receptor\u2010dependent vascular dysfunction in hypertension.<\/jats:p>","DOI":"10.1111\/apha.70321","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:29:46Z","timestamp":1790562586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renin\u2010Angiotensin Signaling and Vascular Function: Insights into Health and Disease"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6498-6671","authenticated-orcid":false,"given":"Giovanni","family":"Bertoldi","sequence":"first","affiliation":[{"name":"Robert M. Berne Cardiovascular Research Center University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9587-9342","authenticated-orcid":false,"given":"Swapnil K.","family":"Sonkusare","sequence":"additional","affiliation":[{"name":"Robert M. Berne Cardiovascular Research Center University of Virginia  Charlottesville Virginia USA"},{"name":"Department of Molecular Physiology and Biological Physics University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2017"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303587"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00723.2018"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10035"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006809"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.08.017"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2005"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47070501"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.203075"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16514"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00175.2008"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028501"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.22856"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.1.148"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0008\u20106363(02)00644\u20102"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.7.1513"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00795364"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.1.73"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2000.4.1.67"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo\u2010120\u20106\u20102334"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116428"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050123"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0008\u20106363(99)00057\u20107"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.83.12.1279"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.11.3.223"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010198910000\u201000004"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111534"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.38.2.243"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.89.1.458"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.20577"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318902"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027097\u20108"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00287.2006"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1043\u20102760(99)00205\u20102"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01179"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.06.011"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.14134"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105253200"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/35024095"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.848816"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0901\u20101003"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051328"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000141428.53262.a4"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(00)01433\u20102"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.06.011"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10266"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000153321.13792.b9"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4641"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1137"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.302882"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022070"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7401157"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.233"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004732"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2006.10.016"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000281"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210971"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/377748a0"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2000.2.1.13"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328349ae0d"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.782138"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164119883978"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176663"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.05.008"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.010454"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010113"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2079"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr059"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.05065"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127891"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07699"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.11.003"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5302"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u20100230\u20103"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2025.61.1.32"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.538934"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.12.049"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.573709"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000032100.23772.98"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.184291"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023877"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010024\u201001062\u20106"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.192138"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx204"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.267054"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003478"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10824"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15058"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102851"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086204"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.216036"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab171"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040371"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.01.020"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15558"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.162800"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4604"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.158626"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.626606"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093112"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz052"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.782841"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy09t1.094005"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.159301"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000187532.80697.15"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.63"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1159\/000163767"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037398"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.015"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04208"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15681"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06163"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.06.028"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.034470"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162941"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.930446"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.188714"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.326648"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg583"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2005.10.005"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.125831"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058607"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023130118"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043385"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c200030"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005052"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216283"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.167809"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00267.2009"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808759105"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608822200"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201014565\u20109"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302168"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.072"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.197863"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.6.6.3"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00760.2010"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035375"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2025.40.S1.0776"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201311050"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmccpl.2023.100055"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2015.02.007"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.37"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00358.2015"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01543"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP287587"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.02.020"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70025"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00127.2015"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272893"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.221010"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307869"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.06591"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2021.106881"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2022.104384"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.03.005"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00826.2012"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000190400.46267.7e"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.312321"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.12.010"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010013\u20101282\u20104"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2891"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13517"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20100577"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.326069"},{"key":"e_1_2_16_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.05.003"},{"key":"e_1_2_16_169_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20601"},{"key":"e_1_2_16_170_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pharmtox\u2010070115\u2010095427"},{"key":"e_1_2_16_171_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05344"},{"key":"e_1_2_16_172_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04794"},{"key":"e_1_2_16_173_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07620"},{"key":"e_1_2_16_174_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08278"},{"key":"e_1_2_16_175_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06565"},{"key":"e_1_2_16_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.12.009"},{"key":"e_1_2_16_177_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000158845.49943.5e"},{"key":"e_1_2_16_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.02.070"},{"key":"e_1_2_16_179_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03618"},{"key":"e_1_2_16_180_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.159525"},{"key":"e_1_2_16_181_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13457"},{"key":"e_1_2_16_182_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000218782.52610.dc"},{"key":"e_1_2_16_183_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.126.327681"},{"key":"e_1_2_16_184_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI195633"}],"container-title":["Acta Physiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apha.70321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:00:55Z","timestamp":1792731655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.70321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":183,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/apha.70321"],"URL":"https:\/\/doi.org\/10.1111\/apha.70321","archive":["Portico"],"relation":{},"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70321"}}