{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:56:22Z","timestamp":1790841382546,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3230090251"],"award-info":[{"award-number":["3230090251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) augments vascular contractility in multiple vascular beds. Fibroblast growth factor 2 (FGF2), whose expression is upregulated in CKD, acts pro\u2010contractile by supporting vasoconstrictor capacity. Thus, the present study tests whether CKD enhances cerebrovascular contractile responses to vasoconstrictors and a role of FGF2 in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established CKD in mice by 5\/6 nephrectomy and a 6% NaCl diet. Cerebrovascular reactivity was assessed in isolated brain basilar arteries and brain medulla oblongata arterioles using wire myography and microperfusion, respectively. Contractile responses to angiotensin II (Ang II), norepinephrine (NE), and endothelin\u20101 (ET\u20101) were measured. Expression of FGF2 and FGF binding protein 1 (FGFBP1) was assessed by immunohistochemistry, enzyme\u2010linked immunosorbent assays, qPCR, and western blot. The role of the FGF2 pathway was evaluated using the selective FGFR tyrosine kinase inhibitor BGJ398.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cerebrovascular contractile responses to Ang II, NE, and ET\u20101 were significantly enhanced in both the brain basilar artery and the brain medulla oblongata arterioles compared with the sham\u2010operated group. FGF2 and FGFBP1 expression were upregulated in brain tissue after CKD, particularly in the medulla oblongata. Treatment with BGJ398 prevented the enhanced cerebrovascular contractile responses in CKD mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CKD enhances cerebrovascular contractile responses to vasoconstrictors, and this effect is mediated by activation of the FGF2 pathway. Targeting the FGF2 pathway may provide treatment of cerebrovascular dysfunction in CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apha.70327","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:04:41Z","timestamp":1790838281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibroblast Growth Factor 2 Enhances Contraction of Arterioles in the Medulla Oblongata and the Basilar Artery in Mice With Chronic Kidney Disease"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-5888","authenticated-orcid":false,"given":"Liang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Nephrology, National Clinical Research Center for Children and Adolescents' Health and Diseases, Provincial Key Laboratory of Neonatal Diseases, Children's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2487-5234","authenticated-orcid":false,"given":"Chunxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, National Clinical Research Center for Children and Adolescents' Health and Diseases, Provincial Key Laboratory of Neonatal Diseases, Children's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8157-6460","authenticated-orcid":false,"given":"Gensheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, National Clinical Research Center for Children and Adolescents' Health and Diseases, Provincial Key Laboratory of Neonatal Diseases, Children's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-2878","authenticated-orcid":false,"given":"Pontus B.","family":"Persson","sequence":"additional","affiliation":[{"name":"Institute of Translational Physiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-6875","authenticated-orcid":false,"given":"Andreas","family":"Patzak","sequence":"additional","affiliation":[{"name":"Institute of Translational Physiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-3806","authenticated-orcid":false,"given":"Jianhua","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, National Clinical Research Center for Children and Adolescents' Health and Diseases, Provincial Key Laboratory of Neonatal Diseases, Children's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-6869","authenticated-orcid":false,"given":"En Yin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-024-21065-9","article-title":"Epidemiological Shifts in Chronic Kidney Disease: A 30\u2010Year Global and Regional Assessment","volume":"24","author":"Qin K.","year":"2024","journal-title":"BMC Public Health"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of Chronic Kidney Disease: An Update 2022","volume":"12","author":"Kovesdy C. 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